2022
DOI: 10.1016/j.apr.2022.101399
|View full text |Cite
|
Sign up to set email alerts
|

Integrated mitoepigenetic signalling mechanisms associated with airborne particulate matter exposure: A cross-sectional pilot study

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
6
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
7
1

Relationship

3
5

Authors

Journals

citations
Cited by 15 publications
(6 citation statements)
references
References 62 publications
0
6
0
Order By: Relevance
“…The results were presented as the fold change was calculated by using the ddCt method, which represents the difference between the Ct values in β-actin and mitogenes treated with FPG enzyme (Ct-T) and samples not treated with FPG enzyme (Ct-UT). A greater ΔCt value indicates augmented oxidative stress in the mitochondria [14].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The results were presented as the fold change was calculated by using the ddCt method, which represents the difference between the Ct values in β-actin and mitogenes treated with FPG enzyme (Ct-T) and samples not treated with FPG enzyme (Ct-UT). A greater ΔCt value indicates augmented oxidative stress in the mitochondria [14].…”
Section: Methodsmentioning
confidence: 99%
“…Some studies have also reported that binding of TNF-α to its receptors induces downstream phosphorylation of p47phox (phox: phagocyte oxidase) and facilitates nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase activity, which further results in mitochondrial dysfunction and mtDNA damage [13]. In response to such disruptions, an adaptive response pathway commonly known as integrated stress response (ISR) is activated [14]. Predominantly, this mechanism is crucial for balanced cellular homeostasis by coordinating with mitochondrial unfolded protein response in an eIF2α dependent pathway [15].…”
Section: Introductionmentioning
confidence: 99%
“…CNAs are released as nucleosomes when cells undergo apoptosis or necrosis. Apart from that, CNAs could be produced by the active metabolic release of DNA from cells . CNAs can be found in healthy and diseased bodies, with diseased ones having higher levels.…”
Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning
confidence: 99%
“…Apart from that, CNAs could be produced by the active metabolic release of DNA from cells. 106 CNAs can be found in healthy and diseased bodies, with diseased ones having higher levels. Increased levels of circulating nucleic acids in the blood can signal some malignant and benign disorders.…”
Section: Circulating Cell-free Nucleic Acids (Ccf-nas) Detection Usin...mentioning
confidence: 99%
“…[25,26] Given that mitochondrial retrograde signaling-induced epigenomic impact is linked to neoplasticity, we adopted a cutting-edge tailored approach that is fundamental to drive these strategies from bench to bedside. [27,28] The dynamic interface between the atmosphere, hydrosphere, cryosphere, and biosphere usually affects the climate and weather patterns at the Earth's surface. [29] The increasing accumulation of greenhouse gases from anthropogenic activities and growing regional concentrations of aerosol particulates are the two most significant drivers of observed climate change since the industrial revolution around 1750.…”
mentioning
confidence: 99%