Integrated MOF-74 Coatings on Magnesium for Corrosion Control, Cytocompatibility, and Antibacterial Properties

Abstract

Biodegradable Mg and its alloys can degrade safely in vivo without toxicity. The major bottleneck inhibiting their clinical use is the high corrosion rate, which leads to the loss of mechanical integrity prematurely and bad biocompatibility. One ideal strategy is the modification with anticorrosive and bioactive coatings. Numerous metal−organic framework (MOF) membranes show satisfactory anticorrosion performance and biocompatibility. In this study, MOF-74 membranes are prepared on an NH 4 TiOF 3 (NTiF) layer-modified Mg matrix, fabricating integrated bilayer coatings (MOF-74/NTiF) for corrosion control, cytocompatibility, and antibacterial properties. The inner NTiF layer serves as the primary protection for the Mg matrix and a stable surface for the growth of MOF-74 membranes. The outer MOF-74 membranes further enhance corrosion protection, whose crystals and thicknesses can be adjusted for different protective effects. Owing to superhydrophilic, micro-nanostructural, and nontoxic decomposition products, MOF-74 membranes significantly promote cell adhesion and proliferation, showing excellent cytocompatibility. Utilizing the decomposition of MOF-74 to generate the products of Zn 2+ and 2,5-dihydroxyterephthalic acid can effectively inhibit Escherichia coli and Staphylococcus aureus, displaying highly efficient antibacterial properties. The research may shed valuable strategies for MOF-based functional coatings in the applications of biomedicine fields.

Advances in Nanomaterials and Composites Based on Mesoporous Materials as Antimicrobial Agents: Relevant Applications in Human Health

“…MOF-74 is a well-known 3D-MOF structure based on Zn 2+ ions connected by 2,5-dihydroxyterephthalate linkers. Recently, MOF-74-based membranes on an NH 4 TiOF 3 (NTiF) layer-modified Mg matrix were prepared for antibacterial, cytocompatibility, and corrosion control properties [37]. Corrosion protection was enhanced by outer MOF-74 membranes whose crystals and thicknesses could be adjusted for several protective effects.…”

Synthesis of Dual p–n Heterojunction of Ni/Mn-MOF-74/CdS@Co3O4 Photocatalyst as a Photoassisted Fenton-like Catalyst for Removal of Tetracycline Hydrochloride

“…As a new type of nanomaterials, metal–organic frameworks (MOFs) materials had been widely used due to their adjustable metal ion centers and diversity of organic ligands, as well as high specific surface area and chemical stability. − Recently, metal–organic frameworks composed of two or more metals could exhibit unique properties and make up for the limitations of MOFs composed of some single metals. At present, MOF-74 was mainly used for the adsorption and separation of CO 2 , − and some studies are used for antibacterial and hydrogen production. , Ni-MOF-74 and Mn-MOF-74 had attracted much attention as one of the most stable structures in the MOF-74 system. Generally speaking, MOF materials could be synthesized by solvothermal method, sonochemical synthesis, and so on .…”