Integrated multi-material portable 3D-printed platform for electrochemical detection of dopamine and glucose

Domingo-Roca, Roger; MacDonald, Alexander; Hannah, Stuart; Corrigan, Damion K.

doi:10.1039/d2an00862a

Cited by 14 publications

(6 citation statements)

References 35 publications

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“…The limit of detection (LOD) was 0.8 μM for the 30% infill electrode ( n = 6), while this was marginally lower at 0.6 μM for the 100% infill electrode. These responses are comparable to other studies which have measured dopamine on graphene/PLA and CB/PLA electrodes . The LOD and sensitivity for the determination of dopamine on the 30% infill electrode were identical to those observed on the 100% electrodes.…”

Section: Resultssupporting

confidence: 87%

Eco-Friendly Approach to Making 3D-Printed Electrochemical Sensors

Shergill,

Bhatia,

Johnstone

et al. 2023

ACS Sustainable Chem. Eng.

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Carbon poly(lactic acid) (PLA)-based 3D-printed electrodes have demonstrated their effectiveness across a diverse spectrum of applications. Nonetheless, the issue of the inadequate natural biodegradability of PLA raises significant sustainability concerns, given the predominate single-use nature of 3D-printed electrochemical sensors. Our study is centered on a systematic approach to understand if reducing the amount of carbon black (CB)/PLA used to make the electrodes can have a significant impact on their performance. CB/PLA electrodes were made with varying amounts of material infill and assessed using cyclic voltammetry with different redox probes. Our findings showcased that there is no difference in the anodic current and electron transfer kinetics of CB/PLA electrodes made using infills from 30% to 100%. When comparing the sensing capabilities of 30% and 100% infill electrodes, no differences were observed in the sensitivity and limit of detection for the measurement of dopamine. Using 30% infill to make electrodes reduces CB/PLA usage by 44%. This approach is of significant utility for the development of 3D-printed electrochemical sensors for a broad range of applications spanning sensing and energy storage. Importantly, this manufacturing approach reduces the use of thermoplastics, which can provide considerable benefits to the environment.

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Section: Resultssupporting

confidence: 87%

Eco-Friendly Approach to Making 3D-Printed Electrochemical Sensors

Shergill,

Bhatia,

Johnstone

et al. 2023

ACS Sustainable Chem. Eng.

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show abstract

“…This was achieved by designing a reservoir‐type structure, a subsided oval‐shaped portion in the device around the three electrodes of a depth of 200 μm. The combined effect of the subsided well design [ 29 ] and hydrophobic nature of resin permitted sample quantities as low as 5 μL and as high as 40 μL to be retained on the device, as shown in Figure S3a–h, Supporting Information, with spillage beginning to occur beyond this point, as depicted in Figure S3i, Supporting Information, when ≈45 μL of sample was added.…”

Section: Resultsmentioning

confidence: 99%

“…[25][26][27][28] It may not be as versatile as a multifunctional device, but it excels in sensing applications, making it appropriate for situations when specialized sensor capabilities are needed. [29][30][31][32] The smart 3D printed mask aims to achieve the former by mitigating the time and complexity factor as much as possible and demonstrating how it can also perform specialized sensing.…”

mentioning

confidence: 99%

3D Printed Design‐Assisted Multilayered Graphene Oxide‐Modified Polymer Glucose Sensor

Das,

Chugh

et al. 2023

Adv Eng Mater

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This work investigates the capabilities of a platform for nonenzymatic glucose sensing employing a novel 3D printed three‐electrode mask‐embedded design. A reservoir‐on‐mask has been fabricated for smart sample insertion to avoid spillage. Working and counter silver electrodes are modified with three different material combinations such as graphene oxide (GO), poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), and GO + PEDOT:PSS, and their performance comparison is demonstrated. It is observed that the GO + PEDOT:PSS modification shows 94.57 and 71.01% higher sensitivity than GO and PEDOT:PSS, respectively, including a higher linearity compared to its counterparts. Glucose concentrations ranging from 50 to 300 mg dL−1are detected by employing cyclic voltammetry and electrical impedance spectroscopic technique. Herein, a significantly high sensitivity of 18.8 μAmM−1 cm−2and low limit of detection ≈ 0.4 mM has been achieved for the proposed sensor. The 3D printed mask structure provides 75% higher sample retention ability, greater reliability in terms of sample placement in the sensor and improved test performances. The proposed sensor can provide a stable and large‐scale deployable solution to future biosensing platforms.

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“…Multi-material 3D-printed sensors were produced as previously described (Domingo-Roca et al, 2022). Briefly, a portable electrochemical biosensor including reference, counter, and working electrodes was 3D-printed in a RAISE3D-E2 IDEX Dual 3D printer (nozzle diameter 0.4 mm) using polylactic acid (PLA, RAISE) as main housing, and carbon black PLA (CB-PLA, ProtoPasta) for the electrodes.…”

Section: D-printingmentioning

confidence: 99%

“…Our previous work demonstrated that (i) functionalisation of SPEs through gel modification improves the measurement duration and can detect a range of microorganisms (Hannah et al, 2019(Hannah et al, , 2020b, and (ii) it is possible to exploit multi-material 3D-printing to produce one-step, portable electrochemical devices to reliably detect a series of redox analytes and life-relevant molecules such as dopamine and glucose (Domingo-Roca et al, 2022). In this work, we combine these two concepts into a novel and rapid approach to antimicrobial susceptibility testing (AST) determination via an impedimetric biosensor.…”

Section: Introductionmentioning

confidence: 99%

Rapid Assessment of Antibiotic Susceptibility Using a Fully 3dprinted Impedance-Based Biosensor

et al. 2022

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Integrated multi-material portable 3D-printed platform for electrochemical detection of dopamine and glucose

Abstract: Design and production of a one-step 3D-printed functional electrochemical biosensor for efficient detection of dopamine and glucose in low-volume samples (100 μL). Glucose detection via ruthenium-mediated amperometry provides results in 60 seconds.

Cited by 14 publications

References 35 publications

Eco-Friendly Approach to Making 3D-Printed Electrochemical Sensors

Eco-Friendly Approach to Making 3D-Printed Electrochemical Sensors

3D Printed Design‐Assisted Multilayered Graphene Oxide‐Modified Polymer Glucose Sensor

Rapid Assessment of Antibiotic Susceptibility Using a Fully 3dprinted Impedance-Based Biosensor

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