Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis

Saiswaroop, R.; Pradhan, Sai Sanwid; M., Datta Darshan V.; Phalguna, Kanikaram Sai; Sivaramakrishnan, Venketesh

doi:10.1007/s13205-022-03401-1

Cited by 8 publications

(3 citation statements)

References 95 publications

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“…Previous studies in our lab have shown that oxidative phosphorylation modulated TDP-43 aggregation in the yeast model of ALS [26]. Similarly, flavonoids from Ginseng were also shown to target the MAPK pathway [27]. Overall, the deregulated pathways show enrichment of metabolic and signalling pathways, which might have implications for protein aggregation and disease.…”

Section: Discussionmentioning

confidence: 61%

“…Previous studies have demonstrated a role for oxidative phosphorylation in FUS, and TDP-43 aggregation in the yeast model of ALS [26]. Further, network-based pharmacology approach has been used to evaluate the role of flavonoids and ginsenosides on FUS and TDP-43 aggregation in ALS [27]. Taken together, the yeast model could be used to understand the role of deregulated pathways on protein aggregation and evaluate them as potential therapeutic targets in ALS.…”

Section: Introductionmentioning

confidence: 99%

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Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Saiswaroop

Soman

Phalguna

et al. 2023

Cells

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Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting the motor neurons, resulting in the death of patients. The disease is either sporadic or familial with SOD1, C9orf72, FUS, and TDP-43 constituting the majority of familial ALS. Multi-omics studies on patients and model systems like mice and yeast have helped in understanding the association of various signaling and metabolic pathways with the disease. The yeast model system has played a pivotal role in elucidating the gene amyloid interactions. We carried out an integrated transcriptomic and metabolomic analysis of the TDP-43 expressing yeast model to elucidate deregulated pathways associated with the disease. The analysis shows the deregulation of the TCA cycle, single carbon metabolism, glutathione metabolism, and fatty acid metabolism. Transcriptomic analysis of GEO datasets of TDP-43 expressing motor neurons from mice models of ALS and ALS patients shows considerable overlap with experimental results. Furthermore, a yeast model was used to validate the obtained results using metabolite addition and gene knock-out experiments. Taken together, our result shows a potential role for the TCA cycle, cellular redox pathway, NAD metabolism, and fatty acid metabolism in disease. Supplementation of reduced glutathione, nicotinate, and the keto diet might help to manage the disease.

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Section: Discussionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Saiswaroop

Soman

Phalguna

et al. 2023

Cells

Self Cite

View full text Add to dashboard Cite

show abstract

“…E-ISSN : 1165-158X / P-ISSN : 0145-5680 www.cellmolbiol.org are turning their attention to Chinese herbal compounds with milder drug effects, in order to find effective drug combinations against these chronic neurological diseases (10)(11)(12). At present, some achievements have been made and important enlightenment has been obtained.…”

Section: Cellular and Molecular Biologymentioning

confidence: 99%

Explore the pharmacological basis of ShengJiYiSui decoction in the treatment of amyotrophic lateral sclerosis based on network pharmacology and molecular docking technology

Song Luo,

Lijuan Yang,

Bo Ma

et al. 2023

Cell Mol Biol (Noisy-le-grand)

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Integrated Multi-Omics Analysis and Validation in Yeast Model of Amyotrophic Lateral Sclerosis

Rajaratnam,

Pradhan,

Naik

et al. 2024

Methods in Molecular Biology

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Integrated network pharmacology approach shows a potential role of Ginseng catechins and ginsenosides in modulating protein aggregation in Amyotrophic Lateral Sclerosis

Cited by 8 publications

References 95 publications

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Explore the pharmacological basis of ShengJiYiSui decoction in the treatment of amyotrophic lateral sclerosis based on network pharmacology and molecular docking technology

Integrated Multi-Omics Analysis and Validation in Yeast Model of Amyotrophic Lateral Sclerosis

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