Integrated optical molecular imaging system for four-dimensional real-time detection in living single cells

Lee, Seung‐Ah; Kang, Seong Ho

doi:10.1016/j.bios.2011.10.053

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…Several approaches for cell culture temperature sensing have been explored in previous works such as commercial T-type thermocouples [13], NTC (negative temperature coefficient) thermistors [14], commercial PT-100 RTDs (resistance temperature detectors) [15], fluorescent polymeric thermometers [16] and optoacoustic methods [17]. However, conventional sensing devices for controlling the cellular microenvironment are not very compact for OoC applications and use expensive and bulky instrumentation equipment [11,18]. Furthermore, optical temperature sensing has poor resolution (~1 • C) and its integration is complex [11].…”

Section: Introductionmentioning

confidence: 99%

Development of Highly Sensitive Temperature Microsensors for Localized Measurements

et al. 2021

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This paper presents the design, fabrication and characterization of temperature microsensors based on Resistance Temperature Detectors (RTDs) with a meander-shaped geometry. Numerical simulations were performed for studying the sensitivity of the RTDs according to their windings numbers as well as for optimizing their layout. These RTDs were fabricated using well-established microfabrication and photolithographic techniques. The fabricated sensors feature high sensitivity (0.3542 mV/°C), linearity and reproducibility in a temperature range of 35 to 45 °C. Additionally, each sensor has a small size with a strong potential for their integration in microfluidic devices, as organ-on-a-chip, allowing the possibility for in-situ monitoring the physiochemical properties of the cellular microenvironment.

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