Integrated PET/CT in the preoperative staging of lung cancer: A prospective comparison of CT, PET and integrated PET/CT

El-Hariri, Mona A.; Gouhar, Ghada K.; Refat, Ali M.

doi:10.1016/j.ejrnm.2012.09.007

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…In the current study, PET-CT changed the plan of treatment in 5 patients. So, we agree with El-Hariri et al [36] and Subedi et al [37] who reported the impact of PET/CT on changing the stage of the disease and the treatment strategy with change in the management plan converting some operable patients to being inoperable and vice versa.…”

Section: According To M Stagingsupporting

confidence: 90%

The added value of18F-FDG PET/CT in staging non-small cell lung cancer

Sheha

Elia

Ghoneim

2019

Egypt J Radiol Nucl Med

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Background: Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancers. The current criteria for its staging are based on the TNM system that determines treatment options and predicts survival rate in patients. The aim of the study was to evaluate the diagnostic accuracy of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography PET/CT in staging of NSCLC patients. Methods: A retrospective study was conducted. We reviewed the CT and PET/CT examinations done in our institution on pathologically proven patients of NSCLC, in the period between October 2018 and end of July 2019. Results: A total of 40 patients were evaluated with the age ranging from 37 to 77 years old, and the mean was 55.63 years (SD ± 10.29). There were 31 male cases and 9 female cases. When we compared contrast enhanced CT (CECT) to PET-CT for staging, PET-CT helped upstage disease in 10 of 40 patients (25%) and downstage in 3 of 40 patients (7.5%). Conclusion: PET/CT is a useful imaging tool in initial staging of the newly diagnosed patients with NSCLC. It is better thаn СT alone fоr detection of malignant lesions for accurate staging. It can change the strategy of treatment according to its findings.

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Section: According To M Stagingsupporting

confidence: 90%

The added value of18F-FDG PET/CT in staging non-small cell lung cancer

Sheha

Elia

Ghoneim

2019

Egypt J Radiol Nucl Med

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“…In the study of Mona A. El-Hariri from 2012, integrated PET-CT appeared to be better than CT alone in mediastinal lymph node staging. Accuracy, sensitivity, specificity, PPV and NPV for detection of malignant lymph nodes was 88%, 89%, 88%, 73% and 100% for PET-CT versus 73%, 78%, 71%, 50% and 94% for CT alone ( 19 ).…”

Section: Discussionmentioning

confidence: 98%

“…The potential surgical cure can also cause certain mortality and morbidity and if disease is so extensive these surgical procedures could be considered futile. So accurate staging of mediastinal lymph nodes provides important prognostic information and is obligatory in determining treatment strategy ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

Advantages of Combined PET-CT in Mediastinal Staging in Patients with Non-small Cell Lung Carcinoma

Bešlić¹,

Šadija²,

Milardović³

et al. 2016

Acta Inform Med

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Introduction:Precise mediastinal lymph node staging in patients with non-small cell lung carcinoma (NSCLC) provides important prognostic information and it is obligatory in treatment strategy planning. 18Fluoro-deoxy-glucose (18F-FDG) positron emission tomography - computerized tomography (PET-CT) based on detection of metabolic activity showed superiority in preoperative staging of lung carcinoma.Materials and Methods:Total number of 26 patients diagnosed with NSCLC were included in this retrospective, cross-sectional study. Status of mediastinal lymph nodes was assessed in all patients comparing contrast enhanced CT and 18F-FDG PET-CT findings.Discussion:We found in our study that 50% of patients had different N stage on contrast enhanced CT comparing to 18F-FDG PET-CT findings. Among the total number of patients which had different nodal status on PET-CT comparing to CT alone, we found in our study that 54% of patients had change in further therapy protocol after PET-CT change of nodal stage.Conclusion:Combined PET-CT which offers advantages of both modalities is excellent method for nodal (N) staging, so it is recommended in initial staging in patients with NSCLC. PET-CT used preopratively for mediastinal nodal staging has significant impact on further therapy planning and also has an consequential impact on health system savings.

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“…The most widely used PET radiotracer is 18F-fluorodeoxyglucose (FDG). 18-FDG being a glucose analogue can enter the tumor cells and phosphorylated by hexokinase without further glucose metabolism, thus becoming trapped in tumor cells allowing the spatial localization and active sites detection [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Thus, FDG can be a very sensitive indicator for glucose-avid cancers. However, inflammatory and infectious processes also show high FDG [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of PET–CT in the evaluation of suspected recurrent ovarian carcinoma

El-Hariri

Harira

Riad

2019

Egypt J Radiol Nucl Med

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Background:The purpose of the current study is to assess the PET/CT potential value in the diagnosis of ovarian cancer recurrence.Results: PET/CT scan described suspicion of ovarian cancer (OC) recurrence in 20 local pelvic lesions with 100% sensitivity, accuracy, and specificity and in 18 peritoneal lesions with sensitivity and specificity of 76.19 and 95.65 and accuracy of 89.55%. While PET/CT suspected OC recurrence in 5 pelvic, 9 para-aortic, and 10 distant lymph nodes, the sensitivity, specificity, and accuracy were (80, 98.38, and 97 %), (66.67, 94.82, and 91.04%), and (90, 98.24, and 97.01), respectively. PET/CT scan described suspicion of OC recurrence in 5 distant organ metastases; the accuracy, sensitivity, and specificity were 100%. The lesion-based accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT scan were 95.77, 85.7, 97.89, 90.5 and 97% while the corresponding patient-based values were 94.44, 96.87, 75, and 94.44% and 96.87 and 75%. Conclusion: PET-CT is a helpful modality in the assessment of OC recurrence; it can detect and localize the recurrence with high accuracy, thus can influence and modify the treatment plan, and reduces the need for 2nd look surgery.

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Integrated PET/CT in the preoperative staging of lung cancer: A prospective comparison of CT, PET and integrated PET/CT

Cited by 9 publications

References 25 publications

The added value of18F-FDG PET/CT in staging non-small cell lung cancer

The added value of18F-FDG PET/CT in staging non-small cell lung cancer

Advantages of Combined PET-CT in Mediastinal Staging in Patients with Non-small Cell Lung Carcinoma

Usefulness of PET–CT in the evaluation of suspected recurrent ovarian carcinoma

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