Integrated phenotyping of the anti-cancer immune response in HIV-associated hepatocellular carcinoma

Pinato, David J.; Kaneko, Takahiro; D’Alessio, Antonio; Forner, Alejandro; Fessas, Petros; Mínguez, Beatriz; Giannini, Edoardo G.; Grillo, Federica; Díaz, Alba; Mauri, Francesco; Fulgenzi, Claudia Angela Maria; Pria, Alessia Dalla; Goldin, Robert; Pieri, Giulia; Toniutto, Pierluigi; Avellini, Claudio; Torres, Maria Corina Plaz; Akarca, Ayse U.; Marafioti, Teresa; Bhoori, Sherrie; Miró, José M.; Bower, Mark; Bräu, Norbert; Mazzaferro, Vincenzo

doi:10.1016/j.jhepr.2023.100741

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“…HCC accounts for nearly half of liver-related mortality in PLWH [78]. HCC seems to have a more aggressive course in HIV+ patients, possibly related to a more profound T cell dysfunction in PLWH compared with controls [79]. Fortunately, the outcomes of LT for HCC do not appear to be affected by HIV infection [57,[80][81][82][83].…”

Section: Malignanciesmentioning

confidence: 99%

Liver Transplantation in People Living with HIV: Still an Experimental Procedure or Standard of Care?

Lynch,

Russo

2023

Life

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Liver transplantation (LT) is the only curative treatment for various liver diseases, including acute liver failure, end-stage liver disease, and selected unresectable liver malignancies. Combination antiretroviral therapy has improved outcomes for people living with HIV (PLWH), transforming the status of acquired immune deficiency syndrome from a fatal disease to a chronic and manageable condition. These powerful antiviral therapies have not only increased the number of HIV+ enlisted patients by improving their survival but also made the use of HIV+ organs a viable option. In this review, we summarise current knowledge on the peculiarities of liver transplantation in PLWH. In particular, we focus on the indications, contraindications, specific considerations for treatment, and outcomes of LT in PLWH. Finally, we present available preliminary data on the use of HIV+ liver allografts.

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