Integrated platform for detecting pathogenic DNA via magnetic tunneling junction-based biosensors

Sharma, Parikshit Pratim; Albisetti, Edoardo; Massetti, Matteo; Scolari, Martina; Torre, Chiara La; Monticelli, Marco; Leone, Marco; Damin, Francesco; Gervasoni, Giacomo; Ferrari, Giorgio; Salice, F.; Cerquaglia, Emanuele; Falduti, Giorgio; Cretich, Marina; Marchisio, Edoardo; Chiari, Marcella; Sampietro, Marco; Petti, Daniela; Bertacco, Riccardo

doi:10.1016/j.snb.2016.11.051

Cited by 54 publications

(34 citation statements)

References 49 publications

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“…The sensor signal first increased as the binding process took place, and a decrease in sensor signal was observed when a washing procedure was conducted. More recent research also demonstrated the detection of different concentrations of DNA extracted from Listeria bacterium with a sensitivity below the nM range [128]. The possibility of multiplexed assay development was also evaluated by examining the orthogonality of the DNA probes.…”

Section: Tmr-based Sensors For Genotypingmentioning

confidence: 99%

Advances in Magnetoresistive Biosensors

Saha

et al. 2019

Micromachines

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Magnetoresistance (MR) based biosensors are considered promising candidates for the detection of magnetic nanoparticles (MNPs) as biomarkers and the biomagnetic fields. MR biosensors have been widely used in the detection of proteins, DNAs, as well as the mapping of cardiovascular and brain signals. In this review, we firstly introduce three different MR devices from the fundamental perspectives, followed by the fabrication and surface modification of the MR sensors. The sensitivity of the MR sensors can be improved by optimizing the sensing geometry, engineering the magnetic bioassays on the sensor surface, and integrating the sensors with magnetic flux concentrators and microfluidic channels. Different kinds of MR-based bioassays are also introduced. Subsequently, the research on MR biosensors for the detection of protein biomarkers and genotyping is reviewed. As a more recent application, brain mapping based on MR sensors is summarized in a separate section with the discussion of both the potential benefits and challenges in this new field. Finally, the integration of MR biosensors with flexible substrates is reviewed, with the emphasis on the fabrication techniques to obtain highly shapeable devices while maintaining comparable performance to their rigid counterparts.

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Section: Tmr-based Sensors For Genotypingmentioning

confidence: 99%

Advances in Magnetoresistive Biosensors

Saha

et al. 2019

Micromachines

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“…TMR sensors have been used to detect small quantities of iron oxide MPs in the complex lymphatic environment with good spatial resolution [ 175 ]. Additionally, a portable system has been integrated with a microfluidic apparatus as a lab-on-a-chip platform to detect pathogenic DNA below nM range sensitivity [ 176 ].…”

Section: Detection Techniques and Their Applicationsmentioning

confidence: 99%

Biosensing Using Magnetic Particle Detection Techniques

Chen

Kolhatkar

Zenasni

et al. 2017

Sensors

148

100

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Magnetic particles are widely used as signal labels in a variety of biological sensing applications, such as molecular detection and related strategies that rely on ligand-receptor binding. In this review, we explore the fundamental concepts involved in designing magnetic particles for biosensing applications and the techniques used to detect them. First, we briefly describe the magnetic properties that are important for bio-sensing applications and highlight the associated key parameters (such as the starting materials, size, functionalization methods, and bio-conjugation strategies). Subsequently, we focus on magnetic sensing applications that utilize several types of magnetic detection techniques: spintronic sensors, nuclear magnetic resonance (NMR) sensors, superconducting quantum interference devices (SQUIDs), sensors based on the atomic magnetometer (AM), and others. From the studies reported, we note that the size of the MPs is one of the most important factors in choosing a sensing technique.

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“…These investigators suggested the utility of this technique in early diagnosis of listeriosis both in clinical and environmental samples. In a recent report, Sharma et al (2017) developed a protocol based on the hybridization of natural DNA, and explored the hybridization events involving genomic DNA extracted from L. monocytogenes through a compact magnetic tunneling junction (MTJ)based biosensing apparatus. In this study, they designed the portable biosensor setup based on MTJ platform to detect L. monocytogenes ( Figure 8A-C).…”

Section: Impedimetric Based Dna Biosensorsmentioning

confidence: 99%

Biosensor for the detection of Listeria monocytogenes: emerging trends

Soni

Ahmad

Dubey

2018

Critical Reviews in Microbiology

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The early detection of Listeria monocytogenes (L. monocytogenes) and understanding the disease burden is of paramount interest. The failure to detect pathogenic bacteria in the food industry may have terrible consequences, and poses deleterious effects on human health. Therefore, integration of methods to detect and trace the route of pathogens along the entire food supply network might facilitate elucidation of the main contamination sources. Recent research interest has been oriented towards the development of rapid and affordable pathogen detection tools/techniques. An innovative and new approach like biosensors has been quite promising in revealing the foodborne pathogens. In spite of the existing knowledge, advanced research is still needed to substantiate the expeditious nature and sensitivity of biosensors for rapid and in situ analysis of foodborne pathogens. This review summarizes recent developments in optical, piezoelectric, cell-based, and electrochemical biosensors for Listeria sp. detection in clinical diagnostics, food analysis, and environmental monitoring, and also lists their drawbacks and advantages.

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Integrated platform for detecting pathogenic DNA via magnetic tunneling junction-based biosensors

Cited by 54 publications

References 49 publications

Advances in Magnetoresistive Biosensors

Advances in Magnetoresistive Biosensors

Biosensing Using Magnetic Particle Detection Techniques

Biosensor for the detection of Listeria monocytogenes: emerging trends

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