Integrated protocol for the prevention and treatment of skin ulcers in patients with end-stage renal disease

Mancin, Stefano; Mazzoleni, Beatrice; Reggiani, Francesco; Calatroni, Marta; Alterchi, Elena; Donizzetti, Daniela; Finazzi, Silvia; Soekeland, Fanny; Sguanci, Marco; Badalamenti, Salvatore

doi:10.1016/j.mex.2023.102482

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Furthermore, signaling of mitophagy might interact with other cellular routes to influence the development of other renal diseases. Among them, CKD might be a major public health concern affecting more than 10% of the global population [111]. In general, dietary restrictions have been used to treat the CKD.…”

Section: Future Perspectivesmentioning

confidence: 99%

Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease

Nakashima,

Suga,

Ikeda

et al. 2024

Biomolecules

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Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease (CKD), and it involves the development of multiple kidney cysts. Not enough medical breakthroughs have been made against PKD, a condition which features regional hypoxia and activation of the hypoxia-inducible factor (HIF) pathway. The following pathology of CKD can severely instigate kidney damage and/or renal failure. Significant evidence verifies an imperative role for mitophagy in normal kidney physiology and the pathology of CKD and/or PKD. Mitophagy serves as important component of mitochondrial quality control by removing impaired/dysfunctional mitochondria from the cell to warrant redox homeostasis and sustain cell viability. Interestingly, treatment with the peroxisome proliferator-activated receptor-α (PPAR-α) agonist could reduce the pathology of PDK and might improve the renal function of the disease via the modulation of mitophagy, as well as the condition of gut microbiome. Suitable modulation of mitophagy might be a favorable tactic for the prevention and/or treatment of kidney diseases such as PKD and CKD.

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Section: Future Perspectivesmentioning

confidence: 99%

Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease

Nakashima,

Suga,

Ikeda

et al. 2024

Biomolecules

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Relational skills of nephrology and dialysis nurses in clinical care settings: A scoping review and stakeholder consultation

Mancin,

Palomares,

Sguanci

et al. 2025

Nurse Education in Practice

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Pilot Implementation of a Primary Care Disease Management Concept for Venous Leg Ulceration: Results of a Mixed-Methods Process Evaluation

Fleischhauer,

Poß-Doering,

Sander

et al. 2024

Healthcare

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Background: Within the project “Ulcus Cruris Care”, a disease management intervention to improve general practice care for patients with venous leg ulcer was developed, comprising online teaching for practice teams, standardized patient education, and case management. Implementation of the intervention was piloted and evaluated via a process evaluation. This study aims to evaluate contentedness with the intervention, implementation effort, implementation determinants, intervention fidelity, and perceived intervention effects using a mixed-methods process evaluation. Methods: The mixed-methods process evaluation explored the views of general practitioners, medical assistants and patients regarding the intervention components. Data were collected through semi-structured telephone interviews and a survey questionnaire. Qualitative data were first analyzed inductively, followed by a deductive–inductive approach based on the Theoretical Domains Framework. Survey data were analyzed descriptively. Results: Participants (n = 21) reported a strong contentedness with the intervention, high intervention fidelity, low implementation effort, and a change in perception of compression therapy as the central treatment element. Healthcare professionals emphasized increased patient education and patient and family involvement. Patients reported feeling better informed and empowered to take an active role in their treatment, primarily due to increased knowledge and skills in compression therapy. As a result, they were more content with their care and reported positive experiences with wound healing since trial participation. Conclusions: The Ulcus Cruris Care intervention can lead to a noticeable change in knowledge and potentially influence practice teams’ approach to venous leg ulcer management, facilitating a significantly more frequent use of compression therapy in VLU care. A confirmatory evaluation of potential effects in a definitive RCT seems warranted.

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Integrated protocol for the prevention and treatment of skin ulcers in patients with end-stage renal disease

Cited by 3 publications

References 13 publications

Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease

Inspiring Tactics with the Improvement of Mitophagy and Redox Balance for the Development of Innovative Treatment against Polycystic Kidney Disease

Relational skills of nephrology and dialysis nurses in clinical care settings: A scoping review and stakeholder consultation

Pilot Implementation of a Primary Care Disease Management Concept for Venous Leg Ulceration: Results of a Mixed-Methods Process Evaluation

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