Medical Image Segmentation is the process of segmenting and detecting boundaries of anatomical structures in various types of 2D and 3D-medical images. The latter come from different modalities, such as Magnetic Resonance Imaging (MRI), X-Rays, Positron Emission Tomography (PET)/Single-Photon Emission Computed Tomography, Computed Tomography (CT), and Ultrasound (US). It is a key supporting technology for medical applications including diagnostics, planning, monitoring, and guidance. Hence, a large number of segmentation methods have been published in past decades. This paper presents a comprehensive review of the current medical segmentation techniques. In particular, we reviewed the most important medical segmentation methods that have been utilized for almost all types of medical images. We grouped these methods into categories and then compared, contrasted, and highlighted their main advantages and limitations.