Many global cities and towns are facing complex and interrelated challenges associated with population growth, resource constraints, aging infrastructure, and degraded environments, exacerbated by increasing climate uncertainty. The United Nation's Agenda 2030 is a global call to action with 17 Sustainable Development Goals (SDGs). Water is the common currency linking nearly every SDG. SDG 11 aspires to ''Make cities and human settlements inclusive, safe, resilient, and sustainable'' and the water-sensitive city represents an aspirational future state for water management where servicing strategies deliver long-term sustainability, liveability, resilience, and prosperity. This social-technical endeavor is based on three principles of practice proposed in 2009. They have since been operationalized and adapted in many projects globally, and across a range of social, institutional, and biophysical contexts. In this Perspective, we reflect on lessons learned, required actions for mainstreaming water-sensitive practices, the next-wave research agenda, and opportunities to catalyze actions in sectors beyond water. ll