This paper investigates a novel robust adaptive dynamic surface control scheme based on the barrier Lyapunov function (BLF), online composite learning, disturbance observer, and improved saturation function. It is mainly designed for a class of skid-to-turn (STT) interceptor integrated guidance and control (IGC) design problems under multi-source uncertainties, state constraints, and input saturation. The serial-parallel estimation model used in this study estimates the system states and provides “critic” information for the neural network and disturbance observer; then, these three are combined to realize online composite learning of the multiple uncertainties of the system and improve the interception accuracy. In addition, the state and input constraints are resolved by adopting the BLF and the improved saturation function, while the design of the auxiliary system ensures stability. Finally, a series of simulation results show that the proposed IGC scheme with a direct-hit intercept strategy achieves a satisfactory effect, demonstrating the validity and robustness of the scheme.