Abstract. A genetic algorithm controlled multispot transmitter is demonstrated to be capable of optimising the received power distribution for single element receivers in fully diffuse mobile indoor optical wireless systems. By dynamically modifying the intensity of individual diffusion spots, the transmitter is capable of compensating for changes in receiver alignment, user movement and surface reflectivity characteristics, with negligible impact to bandwidth and RMS delay spread. The dynamic range, referenced against the peak received power, can be reduced by up to 27% when the room is empty, and up to 26% with user movement and variable receiver alignment. Furthermore, received power perturbation, induced by user movement, is reduced from 10% to 2.5%. This method shows potential for providing a highly adaptable solution of overcoming channel variability whilst also reducing receiver complexity.