Integrated transcriptome and metabolome analysis reveals molecular responses of the clams to acute hypoxia

Sun, Xiujun; Tu, Kang; Li, Li; Wu, Biao; Wu, Lei; Liu, Zhihong; Zhou, Liqing; Tian, Jing; Yang, Aiguo

doi:10.1016/j.marenvres.2021.105317

Cited by 42 publications

(24 citation statements)

References 114 publications

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“…During hypoxia exposure, L-tryptophan levels in tissues increased significantly, which may be caused by blocked energy metabolism (33). Previous studies have shown that hypoxia can lead to the increase of lysine and methionine concentration (34), and it is consistent with the results of this experiment that lysine and methionine concentration increases at high altitude and very high altitude, which may be due to a disturbance of osmotic balance associated with hypoxia (35). A recent metabolic study has shown that a variety of amino acids, including proline, may be involved in the regulation of intracellular osmotic pressure during environmental hypoxia and may act as osmotic fluid (36), which might indicate that proline adapts to hypoxia as an osmolyte.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Metabolic Differences of Jersey Cattle in Different High-Altitude Areas

Kong

Zhou

et al. 2021

Front. Vet. Sci.

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In high-altitude area, hypoxia is a serious stress for humans and other animals, disrupting oxygen homeostasis and thus affecting tissue metabolism. Up to now, there are few reports on the metabolic changes of dairy cows at different altitudes. In this experiment, metabonomics technology and blood biochemical indexes were used to study the metabolic changes of dairy cows in different altitudes. The results showed that the different metabolites were mainly enriched in amino acid metabolism and sphingolipid metabolism, and sphingolipid metabolism showed a negative correlation with increased altitude. The results of this study will enrich the hypoxia-adaptive mechanism of dairy cows in high-altitude areas and provide a theoretical basis for the nutritional regulation of performance and disease treatment of dairy cows in high-altitude areas.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Metabolic Differences of Jersey Cattle in Different High-Altitude Areas

Kong

Zhou

et al. 2021

Front. Vet. Sci.

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“…Conversely, the disruption of the TCA cycle shifts energy pathways from aerobic to anaerobic metabolism [ 43 ]. For invertebrates, anaerobic metabolism produces high levels of alanine and succinic acid as end products [ 44 ]. We found no increase in either succinic acid or alanine in oysters exposed to V. harveyi or LPS, suggesting that a shift from aerobic to anaerobic metabolism did not occur.…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Metabolic Responses of Crassostrea hongkongensis to Infection with Vibrio harveyi and Lipopolysaccharide

Tuo

et al. 2022

Antioxidants

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Gender differences in the hemocyte immune response of Hong Kong oyster Crassostrea hongkongensis to Vibrio harveyi and lipopolysaccharide (LPS) infection exist. To determine if a gender difference also exists, we use a 1H NMR-based metabolomics method to investigate responses in C. hongkongensis hepatopancreas tissues to V. harveyi and LPS infection. Both infections induced pronounced gender- and immune-specific metabolic responses in hepatopancreas tissues. Responses are mainly presented in changes in substances involved in energy metabolism (decreased glucose, ATP, and AMP in males and increased ATP and AMP in LPS-infected females), oxidative stress (decreased glutathione in males and decreased tryptophan and phenylalanine and increased choline and proline in LPS-infected females), tricarboxylic acid (TCA) cycle (decreased α-ketoglutarate acid and increased fumarate in LPS-infected males, and decreased fumarate in LPS-infected females), and osmotic regulation (decreased trigonelline and increased taurine in V. harveyi-infected males and decreased betaine in V. harveyi-infected females). Results suggest that post-spawning-phase male oysters have a more significant energy metabolic response and greater ability to cope with oxidative stress than female oysters. We propose that the impact of oyster gender should be taken into consideration in the aftermath of oyster farming or oyster disease in natural seas.

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“…Thus, the accumulation of acyl-carnitines should be an adaptive phenomenon in barnacles. Similarly, numerous carnitine-conjugated metabolites (mainly acyl-carnitines) have been shown to accumulate in intertidal molluscs at low tide and under hypoosmotic conditions [28][29][30] .…”

Section: Intertidal Zone Adaptation Of Barnaclesmentioning

confidence: 99%

Chromosome-level genome of Capitulum mitella reveals an ancient whole-genome duplication event and intertidal adaptation of barnacles

Yuan

Zhang²,

Zhang

et al. 2022

Preprint

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Barnacles are the only sessile crustaceans inhabiting intertidal zone, an extremely stressful environment for sessile organisms. Herein, we report the chromosome-level genome of a stalked barnacle, Capitulum mitella, which is a dominant intertidal cirripede of the west Pacific Ocean coast. After comprehensive comparative genomic analyses, it is first time to find an ancient whole-genome duplication (WGD) event that preceded the divergence of Lepadomorpha and Sessilia approximately 237 million years ago. The retained duplicated genes of WGD are primarily enriched in many environmental information processing pathways, shedding lights on its adaptive evolution of intertidal sessile life. In addition, transcriptomic and metabolomic sequencing and analyses of C. mitella indicated that the upregulation of some expanded anti-stress factors and accumulation of acyl-carnitines help barnacles adapt to stressful intertidal conditions. Therefore, this study provides a valuable resource for understanding the unique intertidal adaptation mechanism of sessile crustaceans, and reveals novel WGD events in invertebrates.

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Integrated transcriptome and metabolome analysis reveals molecular responses of the clams to acute hypoxia

Cited by 42 publications

References 114 publications

Comparative Analysis of Metabolic Differences of Jersey Cattle in Different High-Altitude Areas

Comparative Analysis of Metabolic Differences of Jersey Cattle in Different High-Altitude Areas

Gender-Specific Metabolic Responses of Crassostrea hongkongensis to Infection with Vibrio harveyi and Lipopolysaccharide

Chromosome-level genome of Capitulum mitella reveals an ancient whole-genome duplication event and intertidal adaptation of barnacles

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