Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats

Han, Hyoung-Yun; Park, Se-Myo; Ko, Je‐Won; Oh, Jung‐Hwa; Kim, Sang Kyum; Kim, Tae Won

doi:10.1007/s43188-022-00156-y

Toxicol Res.

2022

DOI: 10.1007/s43188-022-00156-y

|View full text |Cite

Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats

Hyoung-Yun Han

Se-Myo Park

Je‐Won Ko

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Zhang,

2024

Hum Exp Toxicol

View full text Add to dashboard Cite

Thioacetamide (TAA), a widely employed hepatotoxic substance, has gained significant traction in the induction of liver failure disease models. Upon administration of TAA to experimental animals, the production of potent oxidative derivatives ensues, culminating in the activation of oxidative stress and subsequent infliction of severe damage upon multiple organs via dissemination through the bloodstream. This review summarized the various organ damages and corresponding mechanistic explanations observed in previous studies using TAA in toxicological animal experiments. The principal pathological consequences arising from TAA exposure encompass oxidative stress, inflammation, lipid peroxidation, fibrosis, apoptosis induction, DNA damage, and osteoclast formation. Recent in vivo and in vitro studies on TAA bone toxicity have confirmed that long-term high-dose use of TAA not only induces liver damage in experimental animals but also accompanies bone damage, which was neglected for a long time. By using TAA to model diseases in experimental animals and controlling TAA dosage, duration of use, and animal exposure environment, we can induce various organ injury models. It should be noted that TAA-induced injuries have a time-dependent effect. Finally, in our daily lives, especially for researchers, we should take precautions to minimize TAA exposure and reduce the probability of related organ injuries.

show abstract

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Zhang,

2024

Hum Exp Toxicol

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Integrated transcriptomic analysis of liver and kidney after 28 days of thioacetamide treatment in rats

Cited by 1 publication

References 35 publications

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Unveiling thioacetamide-induced toxicity: Multi-organ damage and omitted bone toxicity

Contact Info

Product

Resources

About