Integrated wireless fast-scan cyclic voltammetry recording and electrical stimulation for reward-predictive learning in awake, freely moving rats

Li, Yu Ting; Wickens, Jeffery R.; Huang, Yi; Pan, Wynn H.T.; Chen, Fu Yu Beverly; Chen, Jia Jin Jason

doi:10.1088/1741-2560/10/4/046007

Cited by 7 publications

(4 citation statements)

References 39 publications

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“…However, DA and NA can be distinguished by targeting different microelectrodes to their respective pathways (Park et al, 2011). Fast cyclic voltammetry can also be used to measure the effects of stimulated DA release (O'Connor and Lowry, 2012) and has recently been further refined by the development of an integrated wireless system which allows both recoding and stimulation in awake, freely moving rats (Li et al, 2013). However, although this represents an important technological advance and rats adapt well to the implants necessary for voltammetry studies, less invasive procedures are of course preferable.…”

Section: New Methods Of Workingmentioning

confidence: 99%

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations

Cassaday

Nelson

Pezze

2014

Front. Syst. Neurosci.

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Distinctions along the dorsal-ventral axis of medial prefrontal cortex (mPFC), between anterior cingulate (AC), prelimbic (PL), and infralimbic (IL) sub-regions, have been proposed on a variety of neuroanatomical and neurophysiological grounds. Conventional lesion approaches (as well as some electrophysiological studies) have shown that these distinctions relate to function in that a number behavioral dissociations have been demonstrated, particularly using rodent models of attention, learning, and memory. For example, there is evidence to suggest that AC has a relatively greater role in attention, whereas IL is more involved in executive function. However, the well-established methods of behavioral neuroscience have the limitation that neuromodulation is not addressed. The neurotoxin 6-hydroxydopamine has been used to deplete dopamine (DA) in mPFC sub-regions, but these lesions are not selective anatomically and noradrenalin is typically also depleted. Microinfusion of drugs through indwelling cannulae provides an alternative approach, to address the role of neuromodulation and moreover that of specific receptor subtypes within mPFC sub-regions, but the effects of such treatments cannot be assumed to be anatomically restricted either. New methodological approaches to the functional delineation of the role of mPFC in attention, learning and memory will also be considered. Taken in isolation, the conventional lesion methods which have been a first line of approach may suggest that a particular mPFC sub-region is not necessary for a particular aspect of function. However, this does not exclude a neuromodulatory role and more neuropsychopharmacological approaches are needed to explain some of the apparent inconsistencies in the results.

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Section: New Methods Of Workingmentioning

confidence: 99%

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations

Cassaday

Nelson

Pezze

2014

Front. Syst. Neurosci.

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“…The physical characteristics and electrochemical performance of this wireless DA and 5-HT sensing system, in comparison with other reported devices, is summarized in Table S1. − Balancing between physical dimensions and electrochemical performance, our device utilizes CV techniques and has demonstrated the capability of detecting multiple neurotransmitters simultaneously with similar LODs compared to previously reported works. For example, the Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) was developed to monitor neurotransmitters in animals.…”

Section: Resultsmentioning

confidence: 93%

Simultaneous Dopamine and Serotonin Monitoring in Freely Moving Crayfish Using a Wireless Electrochemical Sensing System

Han,

Ho,

Stine

et al. 2024

ACS Sens.

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Dopamine (DA) and serotonin (5-HT) are neurotransmitters that regulate a wide range of physiological and behavioral processes. Monitoring of both neurotransmitters with real-time analysis offers important insight into the mechanisms that shape animal behavior. However, bioelectronic tools to simultaneously monitor DA and 5-HT interactive dynamics in freely moving animals are underdeveloped. This is mainly due to the limited sensor sensitivity with miniaturized electronics. Here, we present a semi-implantable electrochemical device achieved by integrating a multisurface-modified carbon fiber microelectrode with a miniaturized potentiostat module to detect DA and 5-HT in vivo with high sensitivity and selectivity. Specifically, carbon fiber microelectrodes were modified through electrochemical treatment and surface coatings to improve sensitivity, selectivity, and antifouling properties. A customized, lightweight potentiostat module was developed for untethered electrochemical measurements. Integrated with the microelectrode, the microsystem is compact (2.8 × 2.3 × 2.1 cm) to minimize its impacts on animal behavior and achieved simultaneous detection of DA and 5-HT with sensitivities of 48.4 and 133.0 nA/μM, respectively, within submicromolar ranges. The system was attached to the crayfish dorsal carapace, allowing electrode implantation into the heart of a crayfish to monitor DA and 5-HT dynamics, followed by drug injections. The semi-implantable biosensor system displayed a significant increase in oxidation peak currents after DA and 5-HT injections. The device successfully demonstrated the application for in vivo simultaneous monitoring of DA and 5-HT in the hemolymph (i.e., blood) of freely behaving crayfish underwater, yielding a valuable experimental tool to expand our understanding of the comodulation of DA and 5-HT.

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“…We found that cocaine enhanced DA release in vivo with an EC 50 of approximately 0.25 mg/kg, which is similar to what others have reported (Li et al . ). This is consistent with its rewarding concentrations.…”

Section: Discussionmentioning

confidence: 97%

Involvement of reactive oxygen species in cocaine‐taking behaviors in rats

et al. 2014

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Reactive oxygen species (ROS) have been implicated in the development of behavioral sensitization following repeated cocaine exposure. We hypothesized that increased ROS following cocaine exposure would act as signaling molecules in the mesolimbic dopamine (DA) system, which might play an important role in mediating the reinforcing effects of cocaine. The aim of this study was to evaluate cocaine enhancement of brain metabolic activity and the effects of ROS scavengers on cocaine self-administration behavior, cocaine-induced ROS production in the nucleus accumbens (NAc) and cocaine enhancement of DA release in the NAc. Metabolic neural activity monitored by temperature and oxidative stress were increased in NAc following cocaine exposure. Systemic administration of the ROS scavenger N-tert-butyl-α-phenylnitrone (PBN) or 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL), either pre- or post-treatment, significantly decreased cocaine self-administration without affecting food intake. Infusion of TEMPOL into the NAc inhibited cocaine self-administration. Increased oxidative stress was found mainly on neurons, but not astrocytes, microglia or oligodendrocytes, in NAc of rats self-administering cocaine. TEMPOL significantly attenuated cocaine-induced enhancement of DA release in the NAc, compared to saline controls. TEMPOL had no effect on the enhancement of DA release produced by the DA transporter inhibitor GBR12909. Taken together, these findings suggest that enhancement of ROS production in NAc neurons contributes to the reinforcing effect of cocaine.

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Integrated wireless fast-scan cyclic voltammetry recording and electrical stimulation for reward-predictive learning in awake, freely moving rats

Cited by 7 publications

References 39 publications

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations

Simultaneous Dopamine and Serotonin Monitoring in Freely Moving Crayfish Using a Wireless Electrochemical Sensing System

Involvement of reactive oxygen species in cocaine‐taking behaviors in rats

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