Integrated X-Ray, NMR, ECD, and Computational Approaches to Assign the Stereochemistry of Nortriterpenoids

Wang, Xiaojuan; Hamann, Mark T.

doi:10.1177/1934578x19849311

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…To determine the absolute configuration of metabolites, singlecrystal X-ray diffraction, NMR advanced Mosher's methods (for alcohols), Marfey's method (for aminoacids) are often used (Bhushan and Brückner, 2011;Cimmino et al, 2017). Computational approaches such as density functional theory (DFT) coupled with (i) NMR, (ii) chiroptical methods e.g., electronical circular dichroism (ECD), vibrational circular dichroism (VCD) spectroscopy and (iii) optical rotation are being successfully employed in identification of relative and absolute configuration of marine natural products (Merten et al, 2015;Batista et al, 2018;Menna et al, 2019;Wang and Hamann, 2019;Fan et al, 2020;Marcarino et al, 2020;Zhu and Sun, 2020). The elucidation of biosynthetic pathways from genomic sequence data is also used to support the absolute configuration assignment (Hu et al, 2018;Kim et al, 2020).…”

Section: Extraction Fractionation Isolation Structure Elucidationmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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Section: Extraction Fractionation Isolation Structure Elucidationmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Kadsura longipedunculata Finet & Gagnepain (Schisandraceae): An Overview of Botany, Traditional Uses, Phytochemistry and Pharmacological Activities

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Zhang

Yaseen

et al. 2022

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Kadsura longipedunculata Finet & Gagnepain (Chinese Kadsura vine) is an evergreen climbing shrub that is widely found in the southwest province of China. The plant can be used as folk medicine to cure canker sores, dysmenorrhea, traumatic injury, insomnia, rheumatoid arthritis, gastrointestinal inflammation, menstrual disorders, and feminine condition. We conducted an open-ended, online database search with the help of Baidu Scholar, CNKI, Elsevier, Scopus, ScienceDirect, Google, Pubmed, and Web of Science for all publications accessible from 1986 to 2022, using the terms related to traditional uses, botany, phytochemistry, and pharmacological properties. A total of ca. 314 phytochemicals were reviewed and identified in K. longipedunculata, with lignans and terpenoids as the predominant groups. The isolated compounds of this plant possess cytotoxic, antioxidant, antitumor, anti-inflammatory, anti-insomnia, anti-trypanosomal, anti-platelet aggregation, hepatoprotective, and other pharmacological effects. This review offers primary data for further research needed to determine the chemical components responsible for its pharmacological effect in order to continue its traditional use. More clinical and preclinical evidence is required to determine the rationale and safety of using K. longipendunculata for medicinal and food purposes.

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Integrated X-Ray, NMR, ECD, and Computational Approaches to Assign the Stereochemistry of Nortriterpenoids

Cited by 2 publications

References 21 publications

The Essentials of Marine Biotechnology

The Essentials of Marine Biotechnology

Kadsura longipedunculata Finet & Gagnepain (Schisandraceae): An Overview of Botany, Traditional Uses, Phytochemistry and Pharmacological Activities

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