This article engages the perpetual denigration of African Traditional Knowledge System (ATKS) by African governments in favor of western biomedical approaches during the COVID-19 pandemic. We demonstrate that the COVID-19 pandemic has once again put the spotlight on the alternative approaches to health and the need for a holistic and broader understanding of these practices in Africa. Using a literature review on health sectors across Africa and cases of traditional health medicines and use in selected countries, we show the Afro cosmo vision and understanding of health, and we make a case for a non-western health approach that is holistic, endogenous, and community-centered. We argue that health approaches need to be anchored on proper understanding of African societies, whose approach to health encompasses the spiritual, emotional, and physical aspect of one’s existence. Our work lends support for the importance of having a multidimensional holistic health system and approach for universal health coverage (UHC) toward the achievement of sustainable development goals (SDGs) in Africa which encompasses ATKS in dealing with pandemics.