The development of information technology has reached the 5th generation known as 5G (Fifth Generation). The need for information technology and industry in all fields is becoming more advanced with 5G. The speed possessed by this information technology is possible for the elimination of human resources because robotic resources replace them with artificial intelligence. The cost of developing modernity, for P Berger, is the fact that 5G technology has reduced human cost because of the replacement of human resources (HR) with technology. To understand human costs and human resource management (HRM) and to deal with global changes in the era of 5G technology, this study applied a qualitative methodology with a library research approach with a sociological paradigm of religion. In the end, the spiritual development of HRM provides an understanding that the religious value of human resources provides space and dimensions of self-esteem for 5G technology. Research Contribution: HRM spiritual development in the 5G era provides space and dimensions of respect for HR's identity as capital to face the 5G era even though HR cannot avoid human costs.