2016
DOI: 10.1016/j.cossms.2016.04.001
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Integrating concepts of material mechanics, ligand chemistry, dimensionality and degradation to control differentiation of mesenchymal stem cells

Abstract: The role of substrate mechanics in guiding mesenchymal stem cell (MSC) fate has been the focus of much research over the last decade. More recently, the complex interplay between substrate mechanics and other material properties such as ligand chemistry and substrate degradability to regulate MSC differentiation has begun to be elucidated. Additionally, there are several changes in the presentation of these material properties as the dimensionality is altered from two- to three-dimensional substrates, which ma… Show more

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Cited by 28 publications
(26 citation statements)
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“…On a molecular level, the polymer chains that make up the network rear-range in response to the load to dissipate the applied force. Thus, in order to better recapitulate the mechanical properties of the native ECM, recent efforts have been directed toward designing hydrogels with tunable viscoelasticity (25).…”
Section: 12mentioning
confidence: 99%
See 1 more Smart Citation
“…On a molecular level, the polymer chains that make up the network rear-range in response to the load to dissipate the applied force. Thus, in order to better recapitulate the mechanical properties of the native ECM, recent efforts have been directed toward designing hydrogels with tunable viscoelasticity (25).…”
Section: 12mentioning
confidence: 99%
“…As for PSCs, the effects of microenvironmental parameters on MSC differentiation have been widely studied. Here, we highlight the major advances and direct the reader to relevant reviews for more detailed information (25,141).…”
Section: Mesenchymal Stem Cellsmentioning
confidence: 99%
“…The physical properties of the cell environment have a significant impact on its fate in terms of survival, proliferation and differentiation. [1][2][3][4][5][6] A major component of the cellular environment is the extracellular matrix (ECM). This porous 3D network of proteoglycans, polysaccharides and fibrous proteins provides a physical scaffold for the cells and initiates important mechano-transduction pathways.…”
Section: Introductionmentioning
confidence: 99%
“…decade, much research has been carried out on the role of the microenvironment, materials, genes and biofactors in guiding differentiation, while great interest has been shown in regulating the controlled differentiation of MSCs (Haugh & Heilshorn, 2016).…”
mentioning
confidence: 99%