The global market competition is becoming increasingly fierce, and manufacturing enterprises need to invest and expand. However, the traditional financial optimization of manufacturing enterprises has faced problems such as low efficiency and inaccurate search for the optimal solution, which has made manufacturing enterprises likely to face financial risks. The investment portfolio can enable enterprises to obtain the maximum profit on a certain risk level, or reduce their investment risk on a certain return level as far as possible. If the combinatorial optimization is realized, it can be applied to the optimal selection of manufacturing enterprises’ financialization. This article analyzed the respective characteristics of Genetic Algorithm (GA) and Simulated Annealing (SA) algorithms, and analyzed the combination of GA and SA algorithms to solve the optimal investment portfolio through GA-SA algorithm, thereby helping manufacturing enterprises to make the optimal choice for financialization. The experimental results of this article indicated that the GA-SA algorithm solved the problem of GA algorithm easily falling into local optima, SA algorithm’s initial temperature and generation mechanism, and improved the efficiency of finding the optimal solution. Meanwhile, the experimental results showed that the average optimal solutions of Genetic Algorithm, Simulated Annealing algorithm, and GA-SA algorithms for 36 stock portfolios in Enterprise 1 were 69, 69, and 107, respectively. The average optimal solutions of the three algorithms for 36 stock portfolios in Enterprise 2 were 73, 90, and 112, respectively. This proves that the number of optimal solutions searched by GA-SA algorithm is higher than that of GA and SA algorithm, and also proves that it is effective to use GA-SA algorithm to optimize investment portfolio and help manufacturing enterprises to make optimal financial choices.
