Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering

Schipani, Rossana; Nolan, David; Lally, Caitríona; Kelly, Daniel J.

doi:10.1080/03008207.2019.1656720

Cited by 48 publications

(34 citation statements)

References 45 publications

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“…Scaffolds made from synthetic polymers temporarily provide mechanical support after implantation, as well as a microenvironment for cell growth, proliferation and differentiation, thereby regulating and inducing tissue differentiation and regeneration ( Li S. et al, 2020 ; Salonius et al, 2020 ). The structure of the scaffold is very important for cartilage regeneration, and tissue engineering applications often require the use of porous three-dimensional (3D) scaffolds to facilitate cell migration and cell-cell interactions ( Schipani et al, 2020 ). Secondly, during the process of regeneration, scaffold should also have sufficient strength to resist the physiological load, and the stress should be properly distributed to the surrounding tissue ( Lohfeld et al, 2015 ).…”

Section: Immunological Characterization Of Biomaterialsmentioning

confidence: 99%

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Liu

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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Biomaterials play a core role in cartilage repair and regeneration. The success or failure of an implanted biomaterial is largely dependent on host response following implantation. Host response has been considered to be influenced by numerous factors, such as immune components of materials, cytokines and inflammatory agents induced by implants. Both synthetic and native materials involve immune components, which are also termed as immunogenicity. Generally, the innate and adaptive immune system will be activated and various cytokines and inflammatory agents will be consequently released after biomaterials implantation, and further triggers host response to biomaterials. This will guide the constructive remolding process of damaged tissue. Therefore, biomaterial immunogenicity should be given more attention. Further understanding the specific biological mechanisms of host response to biomaterials and the effects of the host-biomaterial interaction may be beneficial to promote cartilage repair and regeneration. In this review, we summarized the characteristics of the host response to implants and the immunomodulatory properties of varied biomaterial. We hope this review will provide scientists with inspiration in cartilage regeneration by controlling immune components of biomaterials and modulating the immune system.

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Section: Immunological Characterization Of Biomaterialsmentioning

confidence: 99%

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Liu

Chen

et al. 2021

Front. Bioeng. Biotechnol.

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“…Ec, Ef, Em, and f are composite Young modulus. Young modulus of ACP (Ef = 82 GPa), 33 Young modulus of PCL (Em = 430 MPa), 34 and the ratio of ACP in the mixture, respectively, resulting in a Ec = 477 MPa. As can be seen in Figure 6, on Scaffold A, the element used to generate the mesh was an 8-node brick, widely used in structural analysis.…”

Section: Finite Element Analysismentioning

confidence: 99%

Compression stiffness evaluation of polycaprolactone‐amorphous calcium phosphate 3D‐designed scaffolds oriented by finite element analysis

Liu

Roque

Barbosa

et al. 2021

J of Applied Polymer Sci

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Scaffolds are implants used to accelerate bone regeneration process, being a relevant element of research in bone tissue engineering field. In this context, the proposal of this research was to perform a mechanical behavior evaluation, by finite element analysis (FEA), of two different configurations of 3D scaffolds fabricated in a type of composite material of PCL-ACP (polycaprolactone and amorphous calcium phosphate). The numerical results were compared with the experimental data and also, used to determine the compression stiffness of each studied scaffold configuration. Thus, it was possible to conclude that FEA is a tool that helps understand complex problems while being able to reduce time and cost in analysis, resulting in more efficient and less invasive medical procedures and treatments. In addition, the novelty of this multidisciplinary research work contributes as an application in tissue engineering area by relating a PCL-ACP biomaterial with one unprecedented geometry of scaffold faced to FEA mechanical evaluation. Therefore, demonstrating to be a relevant subject for science by not only providing procedures that increases people's life quality but also for being a new application.

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“…This is especially relevant for the engineering of load bearing tissues, where the scaffold is required to match specific macroscopic mechanical properties and to transduce mechanobiological cues to cells. To explore these design parameters, Schipani et al 5 integrated computational tools of finite element modelling with 3D printing as a way to assess how scaffold architecture and material properties influence the performance of the bioprinted construct. Conversely, Huebner et al 6 investigate the effects of the 3D bioprinted scaffold design parameters on the mechanical properties of the neotissue formed in vivo.…”

Section: Riccardo Gottardimentioning

confidence: 99%

Advances in bioprinting: a toolbox for tissue engineering

Gottardi

2020

Connective Tissue Research

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Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering

Abstract: 15

Cited by 48 publications

References 45 publications

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Compression stiffness evaluation of polycaprolactone‐amorphous calcium phosphate 3D‐designed scaffolds oriented by finite element analysis

Advances in bioprinting: a toolbox for tissue engineering

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