“…We found that many of the genes with increased expression in the hypertrophic region of dorsal lip were already demonstrated to play a role in lip morphogensis and pathobiology in other vertebrates, including alx1 [32], alx3 [33], angptl2 [34], arid3a [35], crip2 [36], ddr2 [37], dpysl2 [38], itga5 [39], lmna [40], mgp [41], rgs5 [42], rhob [42,43], rxfp2 [44], sostdc1 [42,45], thbs3 [46], vcan [47,48], and vtn [49]. Among the transcriptionally repressed genes, we also found candidates with functions which were previously implicated in defective lip morphogenesis in other vertebarates such as cd96 [50], ep300 [51][52], fgfrl1 [53], frzb [54], hectd1 [55,56], mmp13 [49], slc16a6 [57], and syne1 [58].…”