Integrating hydrodynamic and acoustic cell separation in a hybrid microfluidic device: a numerical analysis

Ashkezari, Amir Hossein Kazemipour; Dizani, Mahdi; Shamloo, Amir

doi:10.1007/s00707-022-03206-6

Cited by 12 publications

(3 citation statements)

References 46 publications

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“…Repeated experiments are often required to assess the performance of acoustofluidic separation, which is time-consuming and inconvenient. Some numerical simulation models can partially solve this problem 109 , 110 ; however, discrepancies between simulations and experiments still exist. Recently, Talebjedi et al integrated an artificial neural network (ANN) prediction platform and the multiobjective optimization approach to optimize the performance of acoustic separation 111 , showing the great potential of machine learning methods to aid in experimental design.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Recent advances in acoustofluidic separation technology in biology

et al. 2022

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Acoustofluidic separation of cells and particles is an emerging technology that integrates acoustics and microfluidics. In the last decade, this technology has attracted significant attention due to its biocompatible, contactless, and label-free nature. It has been widely validated in the separation of cells and submicron bioparticles and shows great potential in different biological and biomedical applications. This review first introduces the theories and mechanisms of acoustofluidic separation. Then, various applications of this technology in the separation of biological particles such as cells, viruses, biomolecules, and exosomes are summarized. Finally, we discuss the challenges and future prospects of this field.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Recent advances in acoustofluidic separation technology in biology

et al. 2022

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“…To fully grasp the potential of taSSAW microfluidic devices, further analysis of particle deflection and development in the reliability of the available devices is mandatory, which can be achieved by a numerical and analytical study [ [31] , [32] , [33] ]. Numerical methods have been demonstrated for the reliable design of bioparticle separation microfluidic devices [ [34] , [35] , [36] , [37] , [38] ]. Wang.…”

Section: Introductionmentioning

confidence: 99%

Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics

Peng,

Lin,

et al. 2024

Heliyon

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“…The proficiency of such channels is based on the channel contraction ratio, ℎ. Bifurcation of flow (Chedron et al 1978) arises in electronic cooling equipment, blending vessels, etc. (Shamloo et al 2016;Shamloo and Parast 2019;Boodaghi and Shamloo 2020;Verlinden et al 2020;Ashkezari et al 2022), and it occurs in the case of blood flow in mitral valve because of the irregular spillage of blood, (Fig. 2).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Blood Flow Bifurcation Phenomena in Mitral Valve: A Numerical Approach to Predict Cardiac Arrest

2023

JAFM

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Employing FVM, we have investigated numerically the rheological behavior of bifurcation phenomena of blood flow at various Reynolds numbers (Re) and at various values of contraction ratio (h), defined as the ratio of the inlet to narrow sections width of a two-dimensional planner contraction-expansion channel. Blood flow bifurcation through a planar contraction-expansion channel is analogous to the case of regurgitation (i.e., abnormal leakage of blood) in the mitral valve. In this work, we have studied the blood flow bifurcation characteristics including the normalized axial velocity profile, velocity gradient, dimensionless pressure, dimensionless longitudinal pressure gradient, pressure and skin friction coefficients on both the channel walls and analyzed the pressure drop, excess pressure drop for different values of Re. Secondly, blockage in the mitral valve is studied for different values of h. Pressure drops for various values of h are also studied to measure blood pressure. Correlation analyses are presented for normalized vortex length in terms of critical values of Re and h. It is revealed that if Re goes on increasing to 14.4 or more, flow breaks the symmetry at h = 15, and for each , recirculation length increases linearly with the increase in Re but decreases valve flaps that reduce blood flow to the heart muscles.

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Integrating hydrodynamic and acoustic cell separation in a hybrid microfluidic device: a numerical analysis

Cited by 12 publications

References 46 publications

Recent advances in acoustofluidic separation technology in biology

Recent advances in acoustofluidic separation technology in biology

Investigation on submicron particle separation and deflection using tilted-angle standing surface acoustic wave microfluidics

Analysis of Blood Flow Bifurcation Phenomena in Mitral Valve: A Numerical Approach to Predict Cardiac Arrest

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