2024
DOI: 10.1126/sciadv.ado9120
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Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays

Zan Tan,
Longyou Xiao,
Junwu Ma
et al.

Abstract: A bioinspired hydrogel composed of hyaluronic acid- graft -dopamine (HADA) and a designer peptide HGF-(RADA) 4 -DGDRGDS (HRR) was presented to enhance tissue integration following spinal cord injury (SCI). The HADA/HRR hydrogel manipulated the infiltration of PDGFRβ + cells in a parallel pattern, transforming dense scars into an aligned fibrous substrate that guided axonal regrowth. Further incorporation of NT3 and curcumin promoted axonal… Show more

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Cited by 7 publications
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