The proliferation and increasing application of modern technology have led to the improvement of tactics used to teach to play guzheng, the Chinese national instrument. This study aimed to investigate the effectiveness of using MOOCs (Massive Open Online Courses) for this purpose to argue on the possibility of reforming guzheng instruction in Chinese schools. The basis of this investigation was represented by a specially developed MOOC and an online survey. Verification of the collected data was made by means of Fisher’s exact test. As research participants, 88 seventh graders and 10 teachers from three schools in China (China, Taiyuan, Jinzhong) were invited. The time frame this study covered was from February to June of the 2020-2021 academic year. The outcomes obtained from the conducted experiment indicate that the lowest grades were obtained by students who took traditional guzheng lessons and did not take advantage of online learning (71.1, 72.9, and 73.0 for each institution, with an average of 72.3). At the same time, the results of respondents who were additionally involved in the dedicated MOOC were notably higher: 78.8, 78.1, and 79.2, with an average of 78.7 (8.1% better). These data show that the use of modern technology when teaching students to play guzheng is effective. The outcomes of the survey on students’ impressions from the proposed learning course and its usefulness revealed that 98% of all the persons involved were satisfied with their participation in the MOOC. Students showed high support for the statements claiming MOOC’s positive impact on teachers’ intercultural professionalism in guzheng teaching and overall approach to instruction. The practical and scientific significance of this study resides in the fact that it demonstrates the effectiveness of modern technology, particularly distance learning platforms, in the context of guzheng learning. This paper demonstrates clearly that through the use of additional multimedia, better results can be achieved.