2024
DOI: 10.1007/s12031-024-02249-9
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Integrating Multi-omics to Identify Age-Related Macular Degeneration Subtypes and Biomarkers

Shenglai Zhang,
Ying Yang,
Jia Chen
et al.

Abstract: Age-related macular degeneration (AMD) is one of the most common causes of irreversible vision loss in the elderly. Its pathogenesis is likely multifactorial, involving a complex interaction of metabolic and environmental factors, and remains poorly understood. Previous studies have shown that mitochondrial dysfunction and oxidative stress play a crucial role in the development of AMD. Oxidative damage to the retinal pigment epithelium (RPE) has been identified as one of the major mediators in the pathogenesis… Show more

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