Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury

Wen, Defeng; Han, Wantong; Chen, Quan; Qi, Guanhui; Gao, Mengling; Guo, Pu; Liu, Yu; Wu, Zhongyuan; Fu, Shulin; Lu, Qirong; Qiu, Yinsheng

doi:10.1016/j.toxicon.2023.107531

Toxicon

2024

DOI: 10.1016/j.toxicon.2023.107531

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Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury

Defeng Wen,

Wantong Han,

Quan Chen

et al.

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The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms

Liao,

Xu,

et al. 2024

Veterinary Sciences

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Mycotoxins are secondary metabolites produced by several fungi and moulds that exert toxicological effects on animals including immunotoxicity, genotoxicity, hepatotoxicity, teratogenicity, and neurotoxicity. However, the toxicological mechanisms of mycotoxins are complex and unclear. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is a multimeric cytosolic protein complex composed of the NLRP3 sensor, ASC adapter protein, and caspase-1 effector. Activation of the NLRP3 inflammasome plays a crucial role in innate immune defence and homeostatic maintenance. Recent studies have revealed that NLRP3 inflammasome activation is linked to tissue damage and inflammation induced by mycotoxin exposure. Thus, this review summarises the latest advancements in research on the roles of NLRP3 inflammasome activation in the pathogenesis of mycotoxin exposure. The effects of exposure to multiple mycotoxins, including deoxynivalenol, aflatoxin B1, zearalenone, T-2 toxin, ochratoxin A, and fumonisim B1, on pyroptosis-related factors and inflammation-related factors in vitro and in vivo and the pharmacological inhibition of specific and nonspecific NLRP3 inhibitors are summarized and examined. This comprehensive review contributes to a better understanding of the role of the NLRP3 inflammasome in toxicity induced by mycotoxin exposure and provides novel insights for pharmacologically targeting NLRP3 as a novel anti-inflammatory agent against mycotoxin exposure.

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The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms

Liao,

Xu,

et al. 2024

Veterinary Sciences

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show abstract

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Integrating network pharmacology and experimental validation to explore the mechanisms of luteolin in alleviating fumonisin B1–induced intestinal inflammatory injury

Cited by 1 publication

References 46 publications

The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms

The Novel Role of the NLRP3 Inflammasome in Mycotoxin-Induced Toxicological Mechanisms

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