2021
DOI: 10.3389/fphar.2021.731377
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Integrating Network Pharmacology, Transcriptome and Artificial Intelligence for Investigating Into the Effect and Mechanism of Ning Fei Ping Xue Decoction Against the Acute Respiratory Distress Syndrome

Abstract: Acute respiratory distress syndrome (ARDS) is a high-mortality disease and lacks effective pharmacotherapy. A traditional Chinese medicine (TCM) formula, Ning Fei Ping Xue (NFPX) decoction, was demonstrated to play a critical role in alleviating inflammatory responses of the lung. However, its therapeutic effectiveness in ARDS and active compounds, targets, and molecular mechanisms remain to be elucidated. The present study investigates the effects of NFPX decoction on ARDS mice induced by lipopolysaccharides … Show more

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Cited by 5 publications
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“…6, plays a pivotal role in precision oncology along with potential DL approaches [92]. The availability of individual omics datasets augmented the applications of DL and pharmacogenomics in oncology [93], [94]. Drug response and resistance viz; CDRscan [95], Dr.VAE [96], drug synergism viz; DeepSynergy [97], drug repositioning viz; deep-DR [98], and drug target interactions viz; DeepDTI [99].…”
Section: The New Frontiersmentioning
confidence: 99%
“…6, plays a pivotal role in precision oncology along with potential DL approaches [92]. The availability of individual omics datasets augmented the applications of DL and pharmacogenomics in oncology [93], [94]. Drug response and resistance viz; CDRscan [95], Dr.VAE [96], drug synergism viz; DeepSynergy [97], drug repositioning viz; deep-DR [98], and drug target interactions viz; DeepDTI [99].…”
Section: The New Frontiersmentioning
confidence: 99%