Integrating serum pharmacochemistry and network pharmacology to reveal the mechanism of chickpea in improving insulin resistance

Li, Pei; Zhang, Jiaxian; Wu, Jinyun; Ma, Juanqiong; Huang, Wenyi; Gong, Jing; Xie, Zhiyong; Chen, Yanlong; Liao, Qiongfeng

doi:10.1016/j.fitote.2023.105750

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2024

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Cited by 2 publications

References 44 publications

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Matcha alleviates obesity by modulating gut microbiota and its metabolites

Luo,

Wen,

Huang

et al. 2024

Current Research in Food Science

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Matcha alleviates obesity by modulating gut microbiota and its metabolites

Luo,

Wen,

Huang

et al. 2024

Current Research in Food Science

View full text Add to dashboard Cite

Explore of potential targets and mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments

Wu,

Lin,

et al. 2024

Preprint

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Metabolic dysfunction-associated steatosic liver disease (MASLD) is a serious public health issue globally; however, there is no specific drug treatment. Hesperetin, a flavonoid extracted from citrus, possesses multiple pharmacological properties. However, limited reports have elucidated the pharmacological targets of and molecular mechanisms underlying hesperetin on lipid metabolism disorders in MASLD. First, in vitro experiments confirmed the ameliorative effect of hesperetin on lipid accumulations. Second, putative target genes of the compounds were screened using public databases. MASLD-related targets were obtained through data mining of the GEO database. Third, a PPI network was constructed to screen for the core targets through the STRING database. Additionally, GO and KEGG enrichment analyses were performed on the key targets to identify the enriched genes with specific biological themes. We analyzed the binding mode of hesperetin to the key targets using molecular docking. Finally, the potential mechanism by which hesperetin affects MASLD was validated experimentally on an in vitro model. The current evidence suggested that hesperetin ameliorated lipid accumulation by inhibiting the IL-6-mediated STAT3-SOCS3 signaling pathway. Our findings provided novel insights into the underlying mechanisms and the clinical potential of hesperetin in MASLD management or prevention.

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Integrating serum pharmacochemistry and network pharmacology to reveal the mechanism of chickpea in improving insulin resistance

Cited by 2 publications

References 44 publications

Matcha alleviates obesity by modulating gut microbiota and its metabolites

Matcha alleviates obesity by modulating gut microbiota and its metabolites

Explore of potential targets and mechanisms of hesperetin in treating metabolic dysfunction-associated steatosis liver disease via network pharmacology and in vitro experiments

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