2011
DOI: 10.1021/es1043547
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Integrating Silicon Nanowire Field Effect Transistor, Microfluidics and Air Sampling Techniques For Real-Time Monitoring Biological Aerosols

Abstract: Numerous threats from biological aerosol exposures, such as those from H1N1 influenza, SARS, bird flu, and bioterrorism activities necessitate the development of a real-time bioaerosol sensing system, which however is a long-standing challenge in the field. Here, we developed a real-time monitoring system for airborne influenza H3N2 viruses by integrating electronically addressable silicon nanowire (SiNW) sensor devices, microfluidics and bioaerosol-to-hydrosol air sampling techniques. When airborne influenza … Show more

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Cited by 89 publications
(89 citation statements)
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“…However, more work is needed towards the integration of these technologies with air sampling devices. Shen et al (2011) developed a sensor for real-time detection of influenza H3N2 virus by integrating silicon nanowire field effect transistors, microfluidics and electrostatic air sampling. Although they successfully detected influenza viruses, this device has low charging efficiency for nanometre-sized virus particles, that is, they do not easily get charged and thus not captured efficiently.…”
Section: Detection Of Viruses In Collection Mediamentioning
confidence: 99%
“…However, more work is needed towards the integration of these technologies with air sampling devices. Shen et al (2011) developed a sensor for real-time detection of influenza H3N2 virus by integrating silicon nanowire field effect transistors, microfluidics and electrostatic air sampling. Although they successfully detected influenza viruses, this device has low charging efficiency for nanometre-sized virus particles, that is, they do not easily get charged and thus not captured efficiently.…”
Section: Detection Of Viruses In Collection Mediamentioning
confidence: 99%
“…Biosensors are devices that sense the presence of specific biological entities and translate them into processable information/signal such as voltage or current in electrical biosensors. An MC receiver based on nanoscale Silicon Nanowire (Si-NW) FET has been discussed in detail in [10]. These transistors have antigens placed on Nanowire channel, and binding events between these antigens and virus result in a conductance change across the source-drain channel of the transistor.…”
Section: B Biological Receivermentioning
confidence: 99%
“…Apart from open chamber, a polydimethylsiloxane (PDMS) microfluidic channel has also been exploited to guide fluids flowing through the sensing surface with high controllability, precision, and multiplexing capability, particularly for manipulating samples of minimal volumes. Patolsky and Shen separately directed samples flowing through an SiNW surface for real-time monitoring of airborne influenza H3N2 viruses (Patolsky et al 2004, 2006b, Shen et al 2011. Additionally, we have created a novel SiNW-FET by coupling to a microfluidic polymerase chain reaction (PCR) system that was integrated with heaters and temperature sensors on a silicon chip to shorten the cycling time (Kao et al 2011).…”
Section: Sinw-fet Nanobiosensormentioning
confidence: 99%