Integrating Widely Targeted Lipidomics and Transcriptomics Unravels Aberrant Lipid Metabolism and Identifies Potential Biomarkers of Food Allergies in Rats

Sun, Shanfeng; Li, Kexin; Du, Huiling; Luo, Jiangzuo; Jiang, Yuchi; Wang, Junjuan; Liu, Manman; Liu, Guirong; Han, Shiwen; Che, Huilian

doi:10.1002/mnfr.202200365

Cited by 5 publications

(1 citation statement)

References 84 publications

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“…Metabolic markers have been widely used in food quality, food traceability, and safety research. Through the identification of metabolic markers, we can evaluate food quality and safety [ 36 ]. Significant positive correlations were observed between delphinidin and luteolin based on the correlation analysis of DMs with flavonoids, OPC, TP, DPPH, FRAP, ABTS, P, Ka, Na, Fe, Mn, Cu, and Ca.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice

Gu,

Peng,

Wang

et al. 2023

Metabolites

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Cooking can lead to varying degrees of nutrient loss in purple rice. For this investigation, two varieties of purple rice (YZN1 and YZ6) were chosen as the focal points to explore the metabolites associated with rice nutrition post cooking using nontargeted and targeted metabolomics techniques. The results showed that after cooking the two purple rice varieties, the contents of the flavonoids; OPC; TP; total antioxidant capacity; and K, Na, Fe, Mn, Zn, Cu, Ca, and Mg significantly decreased. Compared with YZN1U (YZN1 uncooked), the amino acid and mineral element contents in YZN1C (YZN1 cooked) decreased to varying degrees. After cooking YZ6, the contents of seven amino acids significantly decreased. Following the preparation of purple rice, the metabolites primarily engaged in the pathways of flavonoid synthesis and flavone and flavonol synthesis. Flavonoids, total antioxidant capacity, mineral elements, and amino acids showed a strong correlation with delphinidin and luteolin. The ROC analysis demonstrated that the value of the area under the curve for delphinidin and luteolin was 1 when comparing YZ6C (YZ6 cooked) and YZ6U (YZ6 uncooked), as well as YZN1C and YZN1U. Delphinidin and luteolin can be used as potential biomarkers of nutrient loss after cooking purple rice. This study holds significant implications for the balanced nutrition and healthy development of human dietary grains.

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Section: Discussionmentioning

confidence: 99%

Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice

Gu,

Peng,

Wang

et al. 2023

Metabolites

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Integrated lipidomic and transcriptomic analyses provide insights into the positive effect of hydrogen peroxide treatment on lipid synthesis in oleaginous red yeast Sporobolomyces pararoseus

Xie,

Zhao,

et al. 2024

LWT

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Allergic inflammation triggers dyslipidemia via IgG signalling

Fernández-Gallego,

Castillo-González,

Moreno-Serna

et al. 2023

Preprint

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Allergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may lead to metabolic disorders, although the underlying mechanisms remain incompletely understood. Here, we show that allergic inflammation induces diet-independent dyslipidemia in a mouse model of allergy and atherosclerosis. Using untargeted lipidomics in mouse plasma, we found that allergic inflammation induces a unique lipid signature that extends beyond acute and late inflammation and that is characterized by triglyceride (TG) changes in circulation. Alterations in blood TGs following an allergic reaction are independent of T-cell-driven late phase inflammation. On the contrary, the humoral component is sufficient to induce a TG increase and a unique lipid profile through the IgG-mediated alternative pathway of anaphylaxis. Lastly, we demonstrated blood TG changes in patients after undergoing an allergic reaction. Overall, this study reveals the importance of IgG-mediated allergic inflammation insofar as it regulates lipid metabolism, which may contribute to atherosclerosis and, ultimately, to cardiovascular events.

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Integrating Widely Targeted Lipidomics and Transcriptomics Unravels Aberrant Lipid Metabolism and Identifies Potential Biomarkers of Food Allergies in Rats

Cited by 5 publications

References 84 publications

Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice

Comparison of Metabolites and Main Nutritional Components between Uncooked and Cooked Purple Rice

Integrated lipidomic and transcriptomic analyses provide insights into the positive effect of hydrogen peroxide treatment on lipid synthesis in oleaginous red yeast Sporobolomyces pararoseus

Allergic inflammation triggers dyslipidemia via IgG signalling

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