This paper is part of a context of galloping evolution of digitalization of all societal areas. This invasion of digital systems and communication that may appear as a progress in many societal applications, as well create new limitations that must be quickly overcome. These limitations may have scientific, technical and technological origin, but also of a human origin, particularly with regard to the nature and the pool of skills, know-how, and innovation capabilities. This paper highlights the future challenges related to the exponential development of connected objects, and Internet of Things that leads to an effective power consumption growing exponentially as well. The different approaches to meet the challenges emphasize the role of microelectronics devices and systems and the potential interest of thin film technologies. It concludes with the human challenge, which is becoming a key point for the success of the digital extension at the global level.