Integration of biomonitoring data and reverse dosimetry modeling to assess population risks of arsenic-induced chronic kidney disease and urinary cancer

Lin, Yueh‐Jaw; Hsiao, Ju Ling; Hsu, Hui-Tsung

doi:10.1016/j.ecoenv.2020.111212

Cited by 19 publications

(3 citation statements)

References 49 publications

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“…According to the table (3) these results agree with previous studies [37,38] Greater arsenic concentrations were found in the serum and packed cells of CKD patients with higher levels of chronic renal insufficiency, indicating a relationship between the level of arsenic accumulation and chronic renal insufficiency [38]. High levels of arsenic in drinking water have been associated with an increase in CKD mortality [37].…”

Section: Heavy Metals In Serum Blood Ckdsupporting

confidence: 87%

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

Aljashamy,

Hussein

2023

IOP Conf. Ser.: Earth Environ. Sci.

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Sampling Blood collected for patients with renal failure of the dialysis group and the non-dialysis group for randomly for (40-60) age. And conduct tests CBC. The oxidation enzymes and some of the sample heavy metal (Ai, Cd, Cr, Pb and As) after digestion and measured in atomic spectrophotometer the result show They found a clear relationship between kidney failure and the effect of heavy metals. Where it affected the blood rate and the number of white blood cells and oxidation enzymes. Where were the values after conducting the tests (12.8 ± 0.45) (9.57 ± 0.62) (9.43 ± 0.47) respectively for control, hemodialysis and non-hemodialysis for Hp. Tests for WBCs (7.8 ± 0.32) (8.07 ± 0.75) (8.37 ± 0.50) respectively for control, hemodialysis and non-hemodialysis. The results of the current study showed in the age group (40_60) that there was a decrease in significant at (P< 0.05) in SOD, GSH and CAT for hemodialysis patients compared with control (0.336±0.035 Mg\dl), (0.4086±0.0041 Mg\dl) and (0.191±0.0051 Mg\dl) Consecutively, according to the table indicated (1-2) and That’s agreement with previous studies. The results of the current study showed in the age group (40_60) that there was a decrease in significant at (P< 0.05) in SOD, GSH and CAT for non-hemodialysis patients compared with control (0.748±0.071 Mg\dl), (0.838±0.019Mg\dl) and (0.335±0.0023 Mg\dl) Consecutively, according to the table indicated (1-2) and That’s agreement with previous studies

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Section: Heavy Metals In Serum Blood Ckdsupporting

confidence: 87%

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

Aljashamy,

Hussein

2023

IOP Conf. Ser.: Earth Environ. Sci.

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“…Reverse dosimetry computes the external exposure from internal organ/plasma concentration or biomarker level in urine (Lin et al, 2020). In this study, the PBPK model was used to reconstruct daily exposure from two cohorts.…”

Section: Exposure Reconstruction Using Child Cohortsmentioning

confidence: 99%

Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model

Deepika

Sharma

Schuhmacher

et al. 2022

Environmental Research

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“…Among them, genetic and environmental factors were two significant factors [ 5 , 6 ]. Many studies have shown that environmental pollutants are closely related to the risk of renal dysfunction [ 7 , 8 , 9 ], including the common pollutants microcystins (MCs) and heavy metals (arsenic [As] and cadmium [Cd]) [ 10 , 11 ]. Our previous study has shown that microcystin-LR (MC-LR) is an independent risk factor for CKD and has a synergistic relationship with Cd [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Combination Effect of Microcystins and Arsenic Exposures on CKD: A Case-Control Study in China

Hong

Zhu

Deng

et al. 2023

Toxins

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Evidence has shown that exposure to environmental pollutants such as microcystins (MCs), arsenic (As), and cadmium (Cd) can lead to the occurrence and development of chronic kidney disease (CKD). There is a synergistic effect between MCs and Cd. However, the combined effect of MCs and As exposures on CKD remains unclear. In Hunan province, China, 135 controls and 135 CKD cases were enrolled in a case-control study. Serum MCs, plasma As and Cd concentrations were measured for all participants. We investigated the association between MCs/As and CKD risk using conditional logistic regression. The additive model explored the interaction effect, and the Bayesian kernel machine regression (BKMR) models investigated the combined effects of MCs, As, and Cd on CKD. The results showed that MCs and As were significantly associated with CKD risk. Participants in the highest MCs concentration had a 4,81-fold increased risk of CKD compared to those in the lowest quartile (95% confidence interval [CI]: 1,96 to 11,81). The highest quartile of As concentrations corresponded to an adjusted odds ratio of 3.40 (95% CI: 1.51, 7.65) relative to the lowest quartile. MCs/As and CKD risk exhibited significant dose–response correlations (all p for trend < 0.01). In addition, a positive interaction effect of MCs and As on CKD was also reported. The CKD risk due to interaction was 2.34 times (95% CI: 0.14, 4.54) relative to the CKD risk without interaction, and the attributable proportion of CKD due to interaction among individuals with both exposures was 56% (95% CI: 0.22, 0.91). In the BKMR, the combined effect of MCs, As, and Cd was positively associated with CKD. In conclusion, both MCs and As are independent risk factors for CKD, exerting a synergistic effect between them. Combined exposure to MCs, As, and Cd can increase the risk of CKD.

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Integration of biomonitoring data and reverse dosimetry modeling to assess population risks of arsenic-induced chronic kidney disease and urinary cancer

Cited by 19 publications

References 49 publications

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

Investigation of some Heavy Metals on Parameter of Blood and Oxidative Enzyme in CKD in Iraq-Al-Qadisiyah

Unravelling sex-specific BPA toxicokinetics in children using a pediatric PBPK model

Combination Effect of Microcystins and Arsenic Exposures on CKD: A Case-Control Study in China

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