Integration of blastocyst transfer for all patients

Wilson, Michael J.; Hartke, Kathy; Kiehl, Michelle; Rodgers, Jonetta; Brabec, Celeste; Lyles, R.

doi:10.1016/s0015-0282(01)03235-6

Cited by 91 publications

(13 citation statements)

References 13 publications

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“…The scientific rationale for blastocyst transfer is to increase implantation rates by improving uterine and embryonic synchronicity and allowing self-selection of embryos with greater implantation potential (Wilson et al ., 2002; Blake et al ., 2007). However, there is little level I evidence on which to base recommendations for morphology screening or blastocyst selection.…”

Section: Embryo Assessmentmentioning

confidence: 99%

Approaches to improve the diagnosis and management of infertility

Devroey¹,

Fauser

Diedrich

2009

Human Reproduction Update

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BACKGROUNDRecent advances in our understanding of the causes of infertility and of assisted reproductive technology (ART) have led to the development of complex diagnostic tools, prognostic models and treatment options. The Third Evian Annual Reproduction (EVAR) Workshop Meeting was held on 26–27 April 2008 to evaluate evidence supporting current approaches to the diagnosis and management of infertility and to identify areas for future research efforts.METHODSSpecialist reproductive medicine clinicians and scientists delivered presentations based on published literature and ongoing research on patient work-up, ovarian stimulation and embryo quality assessment during ART. This report is based on the expert presentations and subsequent group discussions and was supplemented with publications from literature searches and the authors' knowledge.RESULTSIt was agreed that single embryo transfer (SET) should be used with increasing frequency in cycles of ART. Continued improvements in cryopreservation techniques, which improve pregnancy rates using supernumerary frozen embryos, are expected to augment the global uptake of SET. Adaptation and personalization of fertility therapy may help to optimize efficacy and safety outcomes for individual patients. Prognostic modelling and personalized management strategies based on individual patient characteristics may prove to represent real progress towards improved treatment. However, at present, there is limited good-quality evidence to support the use of these individualized approaches.CONCLUSIONSGreater quality control and standardization of clinical and laboratory evaluations are required to optimize ART practices and improve individual patient outcomes. Well-designed, good-quality studies are required to drive improvements to the diagnosis and management of ART processes.

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Section: Embryo Assessmentmentioning

confidence: 99%

Approaches to improve the diagnosis and management of infertility

Devroey¹,

Fauser

Diedrich

2009

Human Reproduction Update

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“…The recommendations made in this guideline were derived mainly from studies of cleavage stage embryos-those cultured for two or three days. Although a recent metaanalysis did not demonstrate a difference in live birth and multiple pregnancy rates between the transfer of cleavage stage embryos and blastocyst embryos cultured for five or six days, [75] several studies have shown higher implantation rates following blastocyst culture, particularly for highquality blastocysts [68,[76][77][78][79][80][81]. A recently published randomized controlled trial of elective single embryo transfer in young women with good prognosis demonstrated a significant improvement in live birth rate following blastocyst compared with cleavage stage transfer [82].…”

Section: Cleavage Stage Vs Blastocyst Stage Embryosmentioning

confidence: 99%

Guidelines for the number of embryos to transfer following in vitro fertilization

Sogc-Cfas¹

2008

International Journal of Gynecology & Obstetrics

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“…Discuss: You can discuss this article with its authors and other readers at https://www.fertstertdialog.com/users/16110-fertilityand-sterility/posts/xfre00002 E mbryo transfer at the blastocyst stage is increasingly accepted and frequently preferred in assisted reproductive technology (ART) centers worldwide, especially in the context of a single-embryo transfer strategy (1,2). Thanks to a better embryo selection, an increase in the implantation rate has been observed in blastocyst compared to cleavage-stage (day-2 to day-3) embryo transfers (3)(4)(5). At the same time, improvement in and the development of blastocyst culture conditions, including efficient media systems, have resulted in wide utilization of extended culture through to the blastocyst stage.…”

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confidence: 99%

Tobacco consumption is associated with slow-growing day-6 blastocysts

et al. 2020

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Objective: To investigate if there are any obvious clinical factors associated with delayed blastulation at day 6 (D6) compared with day 5 (D5). Design: Monocentric observational cohort study from November 2012 to December 2018. Setting: Tertiary-care academic medical center. Patient(s): A total of 941 women with an entire cohort of exclusively D5 blastocysts compared with 162 patients with a cohort of exclusively D6 blastocysts. Intervention(s): None. Main Outcome Measure(s): Clinical characteristics and data related to the ovarian stimulation protocols. Result(s): After univariate analysis, a significantly higher proportion of women who were active smokers was found in the D6 group compared with the D5 group (n ¼ 22/162 [13.6%] vs. n ¼ 82/941 [8.7%]). In addition, the women in the D6 group had a higher rank number of assisted reproductive technology (ART; total no. of ART cycles performed: 2.1 AE 1.4 vs. 1.6 AE 1.1) and a lower antral follicle count (AFC; 18.7 AE 11.3 vs. 22.2 AE 12.8). Moreover, fertilization with the use of intracytoplasmic sperm injection was used more frequently in the D6 group compared with the D5 group. Logistic regression analysis adjusted for confounders highlighted several independent predictors for reaching blastocyst stage at D6 rather than D5: being an active smoker, previous ART cycles, and a lower AFC. Conclusion(s):Obtaining an exclusively D6 blastocyst cohort is independently associated with women who are active smokers, previous ART cycles, and a lower AFC. These findings provide evidence, to be confirmed by further studies, that women who are active smokers could greatly benefit from smoking cessation before undergoing ART.

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Integration of blastocyst transfer for all patients

Cited by 91 publications

References 13 publications

Approaches to improve the diagnosis and management of infertility

Approaches to improve the diagnosis and management of infertility

Guidelines for the number of embryos to transfer following in vitro fertilization

Tobacco consumption is associated with slow-growing day-6 blastocysts

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