Autonomous cars rely on sensors, radars, and lidar infotainment devices to function. They offer a safer solution for road safety, both for the driver and nearby cars. However, they also present a challenge, as ensuring safety requires taking all necessary precautions to ensure the modes of operation and communication of the autonomous car work flawlessly. This is why several research studies have been conducted on the communication protocols used by autonomous cars. These studies have analyzed the weak points of each protocol to propose solutions and improve existing ones. In our previous research papers, we have conducted comparative studies between several communication protocols using software such as OMNETt++. The most important factor that determines the robustness of a protocol is its response time, which ensures communication between the protocols. Some of the protocols that have been studied include C-V2X, DSRC, ITS-G5, and 5G.In this article, a comparative study between the C-V2X and ITS-G5 protocols is conducted based on criteria such as latency, synchronization, resource selection, and response time. This comparison is necessary to improve the operation of the two protocols and ensure the efficiency, reliability, and fluidity of communication between the vehicles and the environment.