Integration of collagen into chitosan blend film composites: physicochemical property aspects for pharmaceutical materials

Abstract

Chitosan and collagen-based hydrogel composites were successfully prepared at chitosan:collagen volume ratio of 1:1, 1:3, 1:5, and 1:10. The structural, thermal, morphological, swelling, mechanical characteristics were investigated, and in vitro degradation testing was conducted. Tetraethyl orthosilicate (TEOS) was used as a crosslinking agent between the chitosan and collagen chains. The NH group of both chitosan and collagen can form crosslinks with the OH groups of TEOS. XRD reported that no significant peak of crystallinity was observed during the integration of collagen into the chitosan film. The surface of the composite was rougher than that of the collagen. The composites were thermally stable up to 200 °C. The glass transition temperature slightly decreased in the presence of collagen. The tensile strength significantly decreased, while the elongation at break significantly increased, when collagen was integrated into the chitosan film. The collagen conferred strong swelling and rapid degradation on the composite. The chitosan/collagen composite films developed in this study have potential applications as pharmaceutical materials.

Adhesive and biodegradable membranes made of sustainable catechol-functionalized marine collagen and chitosan

“…These results indicate that the addition of Coll I enhanced the membranes' swelling ability, probably due to hydrophilic hydroxyl and amine groups from the Coll I amino acids, that bind the water molecules through the hydrogen bonds. Also, the presence of glycerol stabilizes the collagen molecule due to the hydroxyl groups that form hydrogen bonds water molecules [41]. The incorporation of catechol groups at lower concentrations did not change the water uptake of membranes, which is coincident with the literature [42].…”

Development of films based on chitosan, gelatin and collagen extracted from bocachico scales (Prochilodus magdalenae)

“…This increase is due to collagen since it quickly absorbs water. Therefore, the gelatin film has a higher resistance than the chitosan film because the higher the tensile stress value, the higher the film's resistance due to the polymers ' interaction [ 29 ].…”

Collagen-based injectable and self-healing hydrogel with multifunction for regenerative repairment of infected wounds

“…2b , the peak at 1637 cm −1 corresponds to the stretching vibration of C=N [ 39 ], which confirms successful construction of the dynamic hydrogel network basing on Schiff-base bonds. The broad band at 3405 cm −1 should be attributed to the stretching vibrations of O–H and N–H in chitosan [ 40 ]. In the spectra of the COL–CS–OKGM hydrogel, the characteristic peaks at 1687, 1545 and 1247 cm −1 correspond to the amide I (C=O stretching), amide II (N–H bending) and amide III (C–N stretching) bands in collagen macromolecules, respectively [ 41 , 42 ].…”