Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities

Gyapong, John; Gyapong, Margaret; Yellu, Nathaniel; Anakwah, Kwadwo; Amofah, George; Bockarie, Moses J.; Adjei, Sam

doi:10.1016/s0140-6736(09)61249-6

Cited by 136 publications

(117 citation statements)

References 44 publications

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“…Integration into vertical programmes with similar strategies and interventions (LF, onchocerciasis, and STHs) is widely considered to be essential to scale up programmes [85], but the population's acceptability of multiple (simultaneous and staggered) treatments and the degree of community engagement in integrated programmes need to be evaluated. Geostatistical modeling of the often focal and overlapping spatial distribution of individual helminth infections can inform the implementation, monitoring, and evaluation of integrated control programmes [86], [87].…”

Section: Upscaling Interventionmentioning

confidence: 99%

A Research Agenda for Helminth Diseases of Humans: Social Ecology, Environmental Determinants, and Health Systems

et al. 2012

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In this paper, the Disease Reference Group on Helminth Infections (DRG4), established in 2009 by the Special Programme for Research and Training in Tropical Diseases (TDR), with the mandate to review helminthiases research and identify research priorities and gaps, focuses on the environmental, social, behavioural, and political determinants of human helminth infections and outlines a research and development agenda for the socioeconomic and health systems research required for the development of sustainable control programmes. Using Stockols' social-ecological approach, we describe the role of various social (poverty, policy, stigma, culture, and migration) and environmental determinants (the home environment, water resources development, and climate change) in the perpetuation of helminthic diseases, as well as their impact as contextual factors on health promotion interventions through both the regular and community-based health systems. We examine these interactions in regard to community participation, intersectoral collaboration, gender, and possibilities for upscaling helminthic disease control and elimination programmes within the context of integrated and interdisciplinary approaches. The research agenda summarises major gaps that need to be addressed.

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Section: Upscaling Interventionmentioning

confidence: 99%

A Research Agenda for Helminth Diseases of Humans: Social Ecology, Environmental Determinants, and Health Systems

et al. 2012

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“…Programmes could also consider expansion to incorporate deworming, elimination of lymphatic fi lariasis and onchocerciasis, and other neglected disease initiatives as a cost-eff ective means to reduce morbidity and mortality. 117 In response to the second question, disease-specifi c programmes at country level can assist in driving broad improvements throughout the health system, particularly in weak areas such as human resources, laboratory infrastructure, drug forecasting, data monitoring, supervision of peripheral health facilities, and quality assurance. 118 The key issue is how to make this conceptual framework, the undoubted policy development, and the stated international commitment work in practice.…”

Section: Interaction With General Health Systemsmentioning

confidence: 99%

The HIV-associated tuberculosis epidemic—when will we act?

et al. 2010

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Journal LancetRights Reproduced on this site with permission of Elsevier Ltd. Please see [url] Tuberculosis 3The HIV-associated tuberculosis epidemic-when will we act? Anthony D Harries, Rony Zachariah, Elizabeth L Corbett, Stephen D Lawn, Ezio T Santos-Filho, Rhehab Chimzizi, Mark Harrington, Dermot Maher, Brian G Williams, Kevin M De Cock Despite policies, strategies, and guidelines, the epidemic of HIV-associated tuberculosis continues to rage, particularly in southern Africa. We focus our attention on the regions with the greatest burden of disease, especially sub-Saharan Africa, and concentrate on prevention of tuberculosis in people with HIV infection, a challenge that has been greatly neglected. We argue for a much more aggressive approach to early diagnosis and treatment of HIV infection in aff ected communities, and propose urgent assessment of frequent testing for HIV and early start of antiretroviral treatment (ART). This approach should result in short-term and long-term declines in tuberculosis incidence through individual immune reconstitution and reduced HIV transmission. Implementation of the 3Is policy (intensifi ed tuberculosis case fi nding, infection control, and isoniazid preventive therapy) for prevention of HIV-associated tuberculosis, combined with earlier start of ART, will reduce the burden of tuberculosis in people with HIV infection and provide a safe clinical environment for delivery of ART. Some progress is being made in provision of HIV care to HIV-infected patients with tuberculosis, but too few receive co-trimoxazole prophylaxis and ART. We make practical recommendations about how to improve this situation. Early HIV diagnosis and treatment, the 3Is, and a comprehensive package of HIV care, in association with directly observed therapy, short-course (DOTS) for tuberculosis, form the basis of prevention and control of HIV-associated tuberculosis. This call to action recommends that both HIV and tuberculosis programmes exhort implementation of strategies that are known to be eff ective, and test innovative strategies that could work. The continuing HIV-associated tuberculosis epidemic needs bold but responsible action, without which the future will simply mirror the past.

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“…Lymphatic filariasis (LF), commonly known as elephantiasis, is regarded as the second most common global mosquito-borne infectious disease. It is caused by the parasitic filarial nematodes (roundwormsFamily Filariodidea), W. bancrofti (90 % infections), Brugia malayi (9 % infections), or Brugia timori (1 % infections) (Gyapong et al 2010). Nearly 1.4 billion people from 73 countries worldwide are threatened by lymphatic filariasis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of silver and gold nanoparticles using Jasminum nervosum leaf extract and its larvicidal activity against filarial and arboviral vector Culex quinquefasciatus Say (Diptera: Culicidae)

Lallawmawma

Sathishkumar

Sarathbabu

et al. 2015

Environ Sci Pollut Res

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Silver and gold nanoparticles of Jasminum nervosum L. had unique optical properties such as broad absorbance band in the visible region of the electromagnetic spectrum. Characterization of the nanoparticles using UV spectrophotometer, Fourier transform infrared spectroscopy, X-ray diffraction, and transmission electron microscopy confirmed that the particles were silver (AgNPs) and gold (AuNPs) ranging between 4-22 and 2-20 nm with an average particles size of 9.4 and 10 nm, respectively. AgNPs and AuNPs of J. nervosum had high larvicidal activity on the filarial and arboviral vector, Culex quinquefasciatus, than the leaf aqueous extract. Observed lethal concentrations (LC50 and LC95) against the third instar larvae were 57.40 and 144.36 μg/ml for AgNPs and 82.62 and 254.68 μg/ml for AuNPs after 24 h treatment, respectively. The lethal time to kill 50% of C. quinquefasciatus larvae were 2.24 and 4.51 h at 150 μg/ml of AgNPs and AuNPs, respectively, while in the case of aqueous leaf extract of J. nervosum it was 9.44 h at 500 μg/ml (F 2,14 = 397.51, P < 0.0001). The principal component analysis plot presented differential clustering of the aqueous leaf extract, AgNP and AuNPs in relation to lethal dose and lethal time. It is concluded from the present findings that the biosynthesised AgNPs and AuNPs using leaf aqueous extract of J. nervosum could be an environmentally safer nanobiopesticide, and provided potential larvicidal effect on C. quinquefasciatus larvae which could be used for prevention of several dreadful diseases.

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Integration of control of neglected tropical diseases into health-care systems: challenges and opportunities

Cited by 136 publications

References 44 publications

A Research Agenda for Helminth Diseases of Humans: Social Ecology, Environmental Determinants, and Health Systems

A Research Agenda for Helminth Diseases of Humans: Social Ecology, Environmental Determinants, and Health Systems

The HIV-associated tuberculosis epidemic—when will we act?

Synthesis of silver and gold nanoparticles using Jasminum nervosum leaf extract and its larvicidal activity against filarial and arboviral vector Culex quinquefasciatus Say (Diptera: Culicidae)

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