in Wiley Online Library (wileyonlinelibrary.com).Multistage material handling processes are broadly used for manufacturing various products/jobs, where hoists are commonly used to transport inline products according to their processing recipes. When multiple types of jobs with different recipes are simultaneously and continuously handled in a production line, the hoist movement scheduling should be thoroughly investigated to ensure the operational feasibility of every job inline and in the meantime to maximize the productivity if possible. The hoist scheduling will be more complicated, if uncertainties of new coming jobs are considered, that is, the arrival time, type, recipe, and number of new jobs are totally unknown and unpredictable before they join the production line. To process the multiple jobs already inline and the newly added jobs, the hoist movements must be swiftly rescheduled and precisely implemented whenever new job(s) come. Because a reschedule has to be obtained online without violating processing time constraints for each job, the solution identification time for rescheduling must be taken into account by the new schedule itself. All these stringent requisites motivate the development of real-time dynamic hoist scheduling (RDHS) targeting online generation of reschedules for productivity maximization under uncertainties. Hitherto, no systematic and rigorous methodologies have been reported for this study. In this article, a novel RDHS methodology has been developed, which takes into account uncertainties of new coming jobs and targets real-time scheduling optimality and applicability. It generally includes a reinitialization algorithm to accomplish the seamless connection between the previous scheduling and rescheduling operations, and a mixed-integer linear programming model to obtain the optimal hoist reschedule. The RDHS methodology addresses all the major scheduling issues of multistage material handling processes, such as multiple recipes, multiple jobs, multicapacity processing units, diverse processing time requirements, and even optimal processing queue for new coming jobs. The efficacy of the developed methodology is demonstrated through various case studies.