Integration of estimated regional gene expression with neuroimaging and clinical phenotypes at biobank scale
Nhung Hoang,
Neda Sardaripour,
Grace D. Ramey
et al.
Abstract:An understanding of human brain individuality requires the integration of data on brain organization across people and brain regions, molecular and systems scales, as well as healthy and clinical states. Here, we help advance this understanding by leveraging methods from computational genomics to integrate large-scale genomic, transcriptomic, neuroimaging, and electronic-health record data sets. We estimated genetically regulated gene expression (gr-expression) of 18,647 genes, across 10 cortical and subcortic… Show more
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