Integration of Gene-Expression Profiles and Pathway Analysis in Ascending Thoracic Aortic Aneurysms

Kim, Jae Hyun; Na, Chan-Young; Choi, Si Young; Kim, Hwan Wook; Kim, Young Du; Kwon, Jong Bum; Chung, Mee Young; Hong, Jong-Phil; Park, Chan Beom

doi:10.1016/j.avsg.2010.01.007

Cited by 11 publications

(13 citation statements)

References 22 publications

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“…In conclusion, and in concordance with other investigators [20], our study indicates that the weakness of the ascending aortic tissue in TAA is linked with a perturbation of cell adhesion and cell interaction gene expression pathways. MicroRNAs probably act as regulators, possibly driving, or at least influencing, the development of the disease.…”

Section: Discussionsupporting

confidence: 93%

A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms

Patuzzo¹,

Pasquali²,

Malerba³

et al. 2012

Balkan Journal of Medical Genetics

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The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA.This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non familial non syndromic TAA patients (five males and five females) compared to matched control pools. Ninety-nine differentially expressed miRNAs with >1.5-fold-up- or down-regulation in TAAs compared to controls were identified, 16.0% of which were similarly regulated in the two sexes.Genes putatively targeted by differentially expressed miRNAs belonged preferentially to focal adhesion and adherens junction pathways. The results indicate an altered regulation of miRNA-mediated gene expression in the cellular interactions of aneurysmal aortic wall.

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Section: Discussionsupporting

confidence: 93%

A Preliminary microRNA Analysis of non Syndromic Thoracic Aortic Aneurysms

Patuzzo¹,

Pasquali²,

Malerba³

et al. 2012

Balkan Journal of Medical Genetics

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“…Additionally, the chord graph in Figure 6B shows the association of 18 genes with the top 8 GO terms. Interestingly, these results are similar to gene expression profiling of human TAA tissues where focal adhesion and adherens junction pathways were implicated (54,55). Accordingly, the observed differences in gene expression in the Notch1.129S6…”

Section: ;Fbn1supporting

confidence: 75%

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

Koenig¹,

LaHaye²,

Feller³

et al. 2017

JCI Insight

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“…Emr1 and Ptgs2 may represent targets to ameliorate the inflammatory response and limit the diameter expansion in Fbln4 Ϫ/Ϫ AA. It has been shown previously that diseased aortic tissue from TAA patients has different gene expression patterns than normal aortic tissue from control patients (1,9,43,58). Patients with connective tissue disorders, such as Marfan syndrome, or familial forms of TAA were excluded from these studies, so they do not provide insight into molecular mechanisms of aneurysm progression in these cases.…”

Section: Regulated In Fbln4mentioning

confidence: 99%