In this study, electrochemical and structural pitting effect of Artemether/Lumefantrine inhibitive drug was examined as a corrosion inhibitor for mild steel in 0.625M sodium chloride (NaCl) medium using both weight loss and potentiodynamic polarisation method. The effect expired drug was assessed with thermodynamic parameters from temperature variation and adsorption mechanism. Surface morphological assessment was also carried out using scanning electron microscope (SEM) and energy dispersive x-ray spectroscopy (EDS) analyses. The results obtained shows that artemether/lumefantrine inhibits the corrosion of mild steel in 0.625M salt solution fairly well with an inhibition efficiency of up to 75% at 298 K at 20ml of the inhibitor. The inhibition efficiency reduced with increase in temperature but increased with increase in inhibitor concentration which suggests that the inhibition efficiency is inversely proportional to temperature but directly proportional to concentration. It operates with the mixed inhibition method since both the cathodic and anodic reactions were affected by the addition of the inhibitor. Langmuir adsorption isotherm best matches the behaviour of the inhibitor in the study with a minimum correlation coefficient of 0.975.