Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates

Zhu, Huai-He; Zhang, Dan; Wang, Mingwei; Wang, Peiyi; Wu, Yuanyuan; Liu, Liwei; Yang, Song

doi:10.1016/j.jscs.2019.10.002

Cited by 10 publications

(2 citation statements)

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“…27 Many drugs with a 1,3,4-oxadiazole core are being used as antibiotics ( e.g. , ABT-751-oxadiazole, 28 furamizole 29 ), and additionally, zibotentan 30 as an anticancer medicine, raltegravir 31 as an antiviral drug to treat HIV infection, fenadiazole as a hypnotic drug, 32 and tiodazosin as an antihypertensive drug. 33 Numerous oxadiazoles and their derivatives display anticancer activity against various cancer cell types.…”

Section: Introductionmentioning

confidence: 99%

Isolation of potassium salt of oxadiazole-2-thione and in vitro anticancer activities of its Cu(ii) and Zn(ii) complexes against MDA-MB-231 human breast carcinoma cells

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Isolation of potassium salt of oxadiazole-2-thione and in vitro anticancer activities of its Cu(ii) and Zn(ii) complexes against MDA-MB-231 human breast carcinoma cells

et al. 2023

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“…13,14 1,3,4-Oxadiazoles exhibit diverse biological activities including antifungal activity. 12,15–19 Furthermore, many marketed drugs containing a 1,3,4-oxadiazole core were reported including furamizole, 20 oxadiazon, 21 tiodazosin, 22 nesapidil, 23 and zibotentan. 23 A fluconazole derivative with a 1,3,4-oxadiazole moiety showed significant antifungal activity when compared to the parent fluconazole.…”

Section: Introductionmentioning

confidence: 99%

Efficient selective targeting of Candida CYP51 by oxadiazole derivatives designed from plant cuminaldehyde

et al. 2022

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Design, synthesis, antimicrobial activity, and mechanism of novel 3‐(2,4‐dichlorophenyl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazole derivatives

Zheng,

Chen,

Zhang

et al. 2024

Pest Management Science

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BACKGROUNDPlant pathogens cause substantial crop losses annually, posing a grave threat to global food security. Fungicides have usually been used for their control, but the rapid development of pesticide resistance renders many ineffective, therefore the search for novel and efficient green pesticides to prevent and control plant diseases has become the top priority in crop planting.RESULTSThe results of bioassay studies indicated that most of the target compounds showed certain antimicrobial activity in vitro. In particular, compound X7 showed high inhibitory activity against Xanthomonas oryzae pv. oryzae (Xoo), with an EC50 value of 27.47 μg mL−1, surpassing conventional control agents such as thiazole zinc (41.55 μg mL−1) and thiodiazole copper (53.39 μg mL−1). Further studies on molecular docking showed that X7 had a strong binding affinity with 2FBW. The morphological change observed by scanning electron microscopy indicated that the surface of Xoo appears wrinkled and cracked under X7 treatment and a total of 2662 proteins were identified by label‐free proteomic analysis. Three experiments have elucidated the mechanism whereby X7 induced considerable changes in the physiological and biochemical properties of Xoo, which in turn affected the reproduction and growth of bacteria.CONCLUSIONThis work represents a pivotal advancement, offering important reference for the research and development therapeutics in combating plant pathogens. © 2024 Society of Chemical Industry.

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Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates

Cited by 10 publications

References 32 publications

Isolation of potassium salt of oxadiazole-2-thione and in vitro anticancer activities of its Cu(ii) and Zn(ii) complexes against MDA-MB-231 human breast carcinoma cells

Isolation of potassium salt of oxadiazole-2-thione and in vitro anticancer activities of its Cu(ii) and Zn(ii) complexes against MDA-MB-231 human breast carcinoma cells

Efficient selective targeting of Candida CYP51 by oxadiazole derivatives designed from plant cuminaldehyde

Design, synthesis, antimicrobial activity, and mechanism of novel 3‐(2,4‐dichlorophenyl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazole derivatives

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