Integration of paper spray ionization high‐field asymmetric waveform ion mobility spectrometry for forensic applications

Tsai, Chia-Wei; Tipple, Christopher A.; Yost, Richard A.

doi:10.1002/rcm.8068

Cited by 17 publications

(12 citation statements)

References 24 publications

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“…It is necessary to understand the type of reactant ions derived from the ion source [17,28,29]. Using the experimental setup in Figure 4, the UV-MS experiments were performed.…”

Section: Resultsmentioning

confidence: 99%

Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

Hua

Yun

et al. 2019

Micromachines

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A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H2O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS.

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“…It is necessary to understand the type of reactant ions derived from the ion source [17,28,29]. Using the experimental setup in Figure 4, the UV-MS experiments were performed.…”

Section: Resultsmentioning

confidence: 99%

Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

Hua

Yun

et al. 2019

Micromachines

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“…The volume of spray solvent was optimised due to the area of the paper spray substrate here being an order of magnitude larger than in previous work [30,31]. Spray solvent volumes of 20, 50 and 100 μL were tested.…”

Section: Paper Spray Methods Optimisation -Negative Ionsmentioning

confidence: 99%

“…An increase in the threat level associated with terrorist activities has prompted the development of new analysis techniques, and concomitant methods for rapid detection of trace amounts of explosive materials. Several techniques are available, including chemiluminescence [1][2][3][4], thermoredox [3][4][5][6], surface acoustic wave [4,7,8], chemical reagents [9], spectroscopy methods [4,[10][11][12][13], mass spectrometry (MS) and ion mobility spectrometry (IMS) [4,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

“…Several ambient ionisation techniques have been used for explosive detection [38], desorption electrospray ionisation (DESI) [17,18,20,37,39,40], direct analysis real time (DART) [25,27,41], desorption atmospheric pressure chemical ionisation (DAPCI) [42], dielectric barrier discharge (DBDI) [21] and low-temperature plasma (LTP) [26]. Recently, paper spray-mass spectrometry (PS-MS) [43] has been successfully applied to explosives detection [30,31]. This technique, which has been extensively developed for drug detection in blood spots [44] and a variety of other matrices, including fingerprint samples [45], offers the potential for a fast analysis method with high levels of sensitivity.…”

Section: Introductionmentioning

confidence: 99%

“…Tsai et al [30,31] have applied PS-MS for explosives detection for TNT, RDX, HMX and PETN with sensitivities of 1, 0.5, 0.06 and 0.1 ng, respectively. Bain et al [29] also reported detection of these compounds using swab touch ionisation, which follows a similar principle to paper spray.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Rapid, Sensitive and Reliable Detection of Trace Explosives Using Paper Spray Mass Spectrometry (PS‐MS)

Costa

Sears

et al. 2019

Propellants Explo Pyrotec

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In this publication we work towards providing fast, sensitive and selective analysis of explosive compounds collected on swabs using paper spray mass spectrometry. We have (a) increased the size of the paper spray substrate to 1.6×2.1 cm for compatibility with current practise in swabbing for explosive material; (b) developed a method for determining a successful extraction of analyte from the substrate to reduce false negative events; and (c) expanded the range of analytes that can be detected using paper spray to include the peroxide explosive HMTD, as well as nitroglycerine (NG), picric acid (PA) and tetryl. We report the development of a 30 s method for the simultaneous detection of 7 different explosive materials using PS‐MS with detection limits below 25 pg, as well as detection of HMTD at 2500 pg, showing an improvement on previously published work.

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Ambient ionization mass spectrometry applied to new psychoactive substance analysis

Ena

Cowan

Abbate

2021

Mass Spectrometry Reviews

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In the past decade a plethora of drugs with similar effects to controlled psychoactive drugs, like cannabis, amfetamine (amphetamine), or lysergic acid diethylamide, have been synthesized. These drugs can collectively be classified under the term new psychoactive substances (NPS) and are used for recreational purposes. The novelty of the substances, alongside the rapid rate of emergence and structural variability, makes their detection as well as their legal control highly challenging, increasing the demand for rapid and easy-to-use analytical techniques for their detection and identification. Therefore, interest in ambient ionization mass spectrometry applied to NPS has grown in recent years, which is largely because it is relatively fast and simple to use and has a low operating cost. This review aims to provide a critique of the suitability of current ambient ionization techniques for the analysis of NPS in the forensic and clinical toxicology fields. Consideration is given to analytical performance and ease of implementation, including ionization efficiency, selectivity, sensitivity, quantification, analyte chemistry, molecular coverage, validation, and practicality.

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Integration of paper spray ionization high‐field asymmetric waveform ion mobility spectrometry for forensic applications

Cited by 17 publications

References 24 publications

Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

Exploring Rapid, Sensitive and Reliable Detection of Trace Explosives Using Paper Spray Mass Spectrometry (PS‐MS)

Ambient ionization mass spectrometry applied to new psychoactive substance analysis

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