“…Some applications of Bendersbased algorithms for MINLP problems include the optimization of distillation sequences 29 ; the solution of two-stage and multi-stage stochastic MINLP problems, [26][27][28] and the optimal integration of decision layers, for example, simultaneous scheduling and control, process design and operation under stochastic uncertainty, and integrated planning, scheduling and dynamics. 17,32,33 While these methods build upon GBD, the proposed LD-BD strategy incorporates concepts of discrete convex analysis within the LBBD theory to introduce a new type of Benders-based method. Note that the proposed LD-BD method does not incorporate features considered by other Benders methods for MINLPs, for example, including convex relaxations of nonconvex functions within a nonconvex-GBD strategy that guarantees global optimality 26,33 ; adding multiple cuts per iteration to increase convergence speed 17 ; or hybridizing GBD with other methods (e.g., branch and bound) to make the algorithm more efficient.…”