Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes

Fuster, Valentín; Corti, Roberto; Fayad, Zahi A.; Schwitter, Juerg; Badimón, Juan J.

doi:10.1046/j.1538-7836.2003.00271.x

Cited by 36 publications

(10 citation statements)

References 120 publications

(111 reference statements)

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“…[15][16][17][18][19][20] Providing reliable techniques to identify atherosclerotic lesions in the early stages, however, is still challenging. In this study, we could show that alterations of local vascular elasticity precede the formation of atherosclerotic lesions.…”

Section: Discussionmentioning

confidence: 99%

Local Arterial Stiffening Assessed by MRI Precedes Atherosclerotic Plaque Formation

Gotschy

Bauer

Schrodt

et al. 2013

Circ: Cardiovascular Imaging

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) mice, which spontaneously develop atherosclerotic lesions of morphology similar to those observed in humans. 11,12 Local PWV and vessel wall thickness were evaluated by timeresolved flow and morphology measurement using ultrahighfield MR microscopy at 17.6 T. In addition, we performed histological examinations to investigate structural changes of the vessel wall at the time of imaging.Background-Atherosclerosis is known to impair vascular function and cause vascular stiffening. The aim of this study was to evaluate the potential predictive role of vascular stiffening in the early detection of atherosclerosis. Therefore, we investigated the time course of early functional and morphological alterations of the vessel wall in a murine atherosclerosis model. Because initial lesions are distributed inhomogeneously in early-stage atherosclerosis, MR microscopy was performed to measure vascular elasticity locally, specifically the local pulse wave velocity and the arterial wall thickness. Methods and Results-Local pulse wave velocity and the mean arterial wall thickness were determined in the ascending and the abdominal aortae of ApoE −/− and wild-type mice. In vivo MRI revealed that baseline pulse wave velocity and morphology were similar in 6-week-old ApoE −/− and WT mice, whereas at the age of 18 weeks, local pulse wave velocity was significantly elevated in ApoE −/− mice. Significantly increased vessel wall thickness was not found in ApoE −/− mice until the age of 30 weeks. Histological analysis of the aortae of ApoE −/− and WT mice showed that increased pulse wave velocity coincided with the fragmentation of the elastic laminae in the arterial wall, which is hypothesized to induce early vascular stiffening and may be promoted by macrophage-mediated matrix degradation. Conclusions-We

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Section: Discussionmentioning

confidence: 99%

Local Arterial Stiffening Assessed by MRI Precedes Atherosclerotic Plaque Formation

Gotschy

Bauer

Schrodt

et al. 2013

Circ: Cardiovascular Imaging

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“…2 Therefore, an imaging modality able to noninvasively quantify atherosclerotic plaque composition in addition to stenosis might be very useful to detect early atherosclerotic disease and to improve our understanding of its pathogenesis. 3 Moreover, noninvasive imaging of atherosclerosis might potentially improve risk stratification and the clinical management of patients with coronary artery disease, especially those at intermediate risk. 4 Magnetic resonance imaging (MRI) has already demonstrated its ability to noninvasively quantify and characterize atherosclerotic lesions at the preclinical and clinical level.…”

mentioning

confidence: 99%

In Vivo 16-Slice, Multidetector-Row Computed Tomography for the Assessment of Experimental Atherosclerosis

et al. 2004

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Background-Noninvasive imaging can detect early atherosclerotic disease. Magnetic resonance imaging (MRI), because of its excellent spatial resolution, is already established as a tool for plaque characterization. Sixteen-slice, multidetector-row computed tomography (MDCT) was recently introduced into the field of cardiac imaging, with promising results for noninvasive angiography. We compared the capabilities of MDCT and MRI for the assessment of noncalcified, atherosclerotic plaques. Methods and Results-Six atherosclerotic rabbits underwent in vivo imaging by MDCT and 1.5-T MRI. MDCT parameters were 120 kV, 120 mA/s, collimation 12ϫ0.75, and spatial resolution 0.6ϫ0.6 mm. MRI parameters were as follows: for proton density, repetition time/echo time (TR/TE) 2300/5.6; for T2, TR/TE 2300/62; and for T1, TR/TE 800/5.6; slice thickness was 3 mm and spatial resolution, 0.3ϫ0.3 mm. Blinded analysis of 3-mm axial reconstructions from MDCT and the carefully matched MRI images (182 sections) showed excellent agreement between both modalities. MDCT yielded a slightly larger lumen area, anteroposterior diameters, and lateral diameters, with no significant differences in total vessel area. The sensitivity and specificity, respectively, to detect noncalcified, atherosclerotic plaques were 89% and 77% for MDCT and 97% and 94% for MRI. Fibrous-rich and lipid-rich plaque could not be differentiated visually, although they showed different attenuation properties (116Ϯ27 vs 51Ϯ25 Hounsfield units, PϽ0.01). Conclusions-Both techniques allow reliable detection of noncalcified, atherosclerotic plaques and accurate assessment of vessel areas and diameters. MDCT offers the additive value of a very short image acquisition time when compared with MRI. The subtle measurement differences found between modalities may be due to the better spatial resolution of MRI, which probably explains its superiority for tissue characterization.

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“…Multiple pathological, angiographic and clinical studies suggest that atherosclerosis, a systemic disease that can be quiescent for years, dramatically changes the natural history when complicated by coronary thrombosis [3]. High-risk plaques (local) and increased thrombogenicity (systemic) interact to precipitate coronary thrombosis.…”

Section: Introductionmentioning

confidence: 99%

Understanding atherothrombosis: from vulnerable plaque to vulnerable patient

Moreno

Corti

Fuster

2004

International Congress Series

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Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes

Cited by 36 publications

References 120 publications

Local Arterial Stiffening Assessed by MRI Precedes Atherosclerotic Plaque Formation

Local Arterial Stiffening Assessed by MRI Precedes Atherosclerotic Plaque Formation

In Vivo 16-Slice, Multidetector-Row Computed Tomography for the Assessment of Experimental Atherosclerosis

Understanding atherothrombosis: from vulnerable plaque to vulnerable patient

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