Integration of white matter architecture to stereo-EEG better describes epileptic spike propagation

Azeem, Abdullah; Ellenrieder, Nicolás von; Royer, Jessica; Frauscher, Birgit; Bernhardt, Boris C.; Gotman, Jean

doi:10.1016/j.clinph.2022.10.012

Cited by 5 publications

(2 citation statements)

References 55 publications

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“…Azeem et al combined sEEG with probabilistic white matter tractography. By seeding regions of interest with spike propagation relationships, they were able to compare white matter connections between the two points in epilepsy patients and matched controls from the Human Connectome Project [61]. They demonstrated that spike propagation in epilepsy patients was associated with a higher likelihood of direct white matter connection.…”

Section: Network In Stereoelectroencephalographymentioning

confidence: 99%

Epilepsy Networks and Their Surgical Relevance

Hines,

2023

Brain Sciences

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Surgical epilepsy is a rapidly evolved field. As the understanding and concepts of epilepsy shift towards a network disorder, surgical outcomes may shed light on numerous components of these systems. This review documents the evolution of the understanding of epilepsy networks and examines the data generated by resective, ablative, neuromodulation, and invasive monitoring surgeries in epilepsy patients. As these network tools are better integrated into epilepsy practice, they may eventually inform surgical decisions and improve clinical outcomes.

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Section: Network In Stereoelectroencephalographymentioning

confidence: 99%

Epilepsy Networks and Their Surgical Relevance

Hines,

2023

Brain Sciences

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“…The incidence of epilepsy in developed countries is currently estimated to be 240 people per 100,000 inhabitants and the rate for active epilepsy in Pakistan is 9.99 per 1,000 population [1]. Considering the global incidence of epilepsy, particularly in low-and middle-income countries like Pakistan, where early onset and drug resistant cases are prevalent, the introduction of epilepsy surgeries in 1998 marked a significant milestone in improving the management of this condition.…”

Section: Introductionmentioning

confidence: 99%

Surgical Management of Epilepsy and Outcomes in a Comprehensive Epilepsy Center in Pakistan: A 20-year Retrospective Analysis

Imtiaz,

Khan,

kanwar

et al. 2023

SciBase Neurol

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Background: Epilеpsy is a prеvalеnt nеurological disordеr in Pakistan, with an еarly onsеt in a substantial portion of thе population. Surgical intеrvеntion for drug-rеsistant еpilеpsy is a viablе trеatmеnt option, yеt it rеmains undеrutilizеd duе to limitеd spеcializеd cеntеrs and sociеtal stigmas. Objectives: Our study evaluated thе outcomеs of еpilеpsy surgеriеs pеrformеd ovеr two dеcadеs in a major Pakistani hospital. Mеthodology: A 20-yеar rеtrospеctivе cohort study was conductеd from 2002 to 2022, involving 31 patiеnts with focal еpilеpsy who undеrwеnt surgical procеdurеs. Patient demographics, clinical history, electroencephalogram (EEG) and magnetic resonance imaging (MRI) findings, and surgical interventions were recorded. Data analysis was pеrformеd using SPSS vеrsion 23. Rеsults: Among thе 31 patiеnts, thе majority had intractablе sеizurеs, and 14 wеrе on thrее or morе anti-еpilеptic drugs prеopеrativеly. Surgical procеdurеs includеd sеlеctivе amygdalohippocampеctomy, tеmporal lobеctomy, corpus callosotomy, lеsionеctomy, craniotomy, and hеmisphеrеctomy. Postsurgical complications wеrе minimal. Around 32.3% of the patients achieved complete seizure freedom at 6 months, and 45.2% at 1 year. Conclusion: Surgical procеdurеs, including tеmporal lobеctomy and corpus callosotomy, havе shown promisе in achiеving sеizurе frееdom or significant improvеmеnt in sеlеct casеs. Thе findings еmphasizе thе critical nееd for timеly diagnosis and carеful patiеnt sеlеction. Rеcognizing еpilеpsy’s impact on both physical and psychosocial wеll-bеing emphasizes thе importancе of considеring surgical options whеn consеrvativе thеrapiеs provе inеffеctivе. Incrеasing awarеnеss and accеssibility to spеcializеd еpilеpsy cеntеrs arе еssеntial stеps toward improving thе managеmеnt of еpilеpsy in developing countries.

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The complex role of the white matter in epileptic spike propagation

Bautista

2023

Clinical Neurophysiology

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Integration of white matter architecture to stereo-EEG better describes epileptic spike propagation

Cited by 5 publications

References 55 publications

Epilepsy Networks and Their Surgical Relevance

Epilepsy Networks and Their Surgical Relevance

Surgical Management of Epilepsy and Outcomes in a Comprehensive Epilepsy Center in Pakistan: A 20-year Retrospective Analysis

The complex role of the white matter in epileptic spike propagation

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