Integrative Analyses of Biomarkers and Pathways for Osteosarcopenia

Li, Yang; Sun, Jun

doi:10.21203/rs.3.rs-283082/v1

Cited by 1 publication

(1 citation statement)

References 33 publications

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“…The tissues in the osteoporosis datasets are blood monocytes, while the tissues in the sarcopenia datasets are the vastus lateralis muscle. 66 In parallel, an interesting RNA-sequencing study in elderly osteoporotic hip fracture sarcopenic and non-sarcopenic subjects was performed. A total of 11 samples from both groups were sequenced, and 15 DEGs were identified ( RUNX1, NGFR, CH3L1, BCL3, PLA2G2A, MYBPH, TEP1, SEMA6B, CSPG4, ACSL5, SLC25A3, NDUFB5, CYC1, ACAT1 and TCAP ).…”

Section: Genetics Of Bone and Muscle Interactionsmentioning

confidence: 99%

Sarcopenia and bone health: new acquisitions for a firm liaison

Tarantino

Greggi

Visconti

et al. 2022

Therapeutic Advances in Musculoskeletal

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Osteosarcopenia (OS) is a newly defined condition represented by the simultaneous presence of osteopenia/osteoporosis and sarcopenia, the main age-related diseases. The simultaneous coexistence of the two phenotypes derives from the close connection of the main target tissues involved in their pathogenesis: bone and muscle. These two actors constitute the bone–muscle unit, which communicates through a biochemical and mechanical crosstalk which involves multiple factors. Altered pattern of molecular pathways leads to an impairment of both the functionality of the tissue itself and the communication with the complementary tissue, composing the OS pathogenesis. Recent advances in the genetics field have provided the opportunity to delve deeper into the complex biological and molecular mechanisms underlying OS. Unfortunately, there are still many gaps in our understanding of these pathways, but it has proven essential to apply strategies such as exercise and nutritional intervention to counteract OS. New therapeutic strategies that simultaneously target bone and muscle tissue are limited, but recently new targets for the development of dual-action drug therapies have been identified. This narrative review aims to provide an overview of the latest scientific evidence associated with OS, a complex disorder that will pave the way for future research aimed at understanding the bone–muscle-associated pathogenetic mechanisms.

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Section: Genetics Of Bone and Muscle Interactionsmentioning

confidence: 99%