Integrative Analysis of Potential Biomarkers Involved in the Progression of Papillary Thyroid Cancer

Bansal, Ritu; Saxena, Urmila

doi:10.1007/s12010-022-04244-5

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…In addition, this analysis links gene changes to relevant diseases, suggesting their potential as disease markers and insights into therapeutic targets [96] , [97] . Finally, it supports the validation and refinement of biomarkers, ensuring their clinical relevance and accuracy [98] , [99] , [100] . For instance, Chen, G. et al 2021 performed pathway enrichment to investigate the biological function of DEGs in breast cancer.…”

Section: Pathway Enrichment Analysismentioning

confidence: 63%

Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review

Rosati,

Palmieri,

Brunelli

et al. 2024

Computational and Structural Biotechnology Journal

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Section: Pathway Enrichment Analysismentioning

confidence: 63%

Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review

Rosati,

Palmieri,

Brunelli

et al. 2024

Computational and Structural Biotechnology Journal

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“…Consequently, they evolve into iodine-refractory thyroid cancer, leading to recurrence, distant metastasis, and ultimately, death 9 . The invasion and metastasis of PTC is a complex multi-stage process regulated by multiple genes, multiple factors, and multiple signaling pathways, involving the decline of adhesion between cancer cells and the cell matrix, extracellular matrix degradation, tumor cell migration, distant colonization and other links 10 , 11 . Therefore, the molecular mechanism of invasion and metastasis of PTC has been unclear.…”

Section: Introductionmentioning

confidence: 99%

USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination

Wang,

Ye,

Wang

et al. 2024

J. Cancer

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Purpose: Papillary thyroid cancer (PTC) stands as one of the most prevalent types of thyroid cancers, characterized by a propensity for in-situ recurrence and distant metastasis. The high mobility group protein (HMGB1), a conserved nuclear protein, plays a pivotal role in carcinogenesis by stimulating tumor cell growth and migration. Nevertheless, the underlying mechanism driving aberrant HMGB1 expression in PTC necessitates further elucidation. Materials and methods: Our study unraveled the impact of low and overexpression of USP15 on the proliferation, invasion, and metastasis of PTC cells. Through a comprehensive array of molecular techniques, we uncovered the intricate relationship between HMGB1 and USP15 in the progression of PTC. Results: In this study, we identified USP15, a deubiquitinase in the ubiquitin-specific proteases family, as a true deubiquitylase of HMGB1 in PTC. USP15 was shown to interact with HMGB1 in a deubiquitination activity-dependent manner, deubiquitinating and stabilizing HMGB1. USP15 depletion significantly decreased PTC cell proliferation, migration, and invasion. In addition, the effects induced by USP15 depletion could be rescued by further HMGB1 overexpression. But when HMGB1 is knocked down, even overexpression of USP15 could not promote the progression of PTC cells. Conclusion: In essence, our discoveries shed light on the previously uncharted catalytic role of USP15 as a deubiquitinating enzyme targeting HMGB1, offering a promising avenue for potential therapeutic interventions in the management of PTC.

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Integrative Analysis of Potential Biomarkers Involved in the Progression of Papillary Thyroid Cancer

Cited by 2 publications

References 22 publications

Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review

Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: A review

USP15 promotes the progression of papillary thyroid cancer by regulating HMGB1 stability through its deubiquitination

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