Integrative Analysis of Regulatory Module Reveals Associations of Microgravity with Dysfunctions of Multi-body Systems and Tumorigenesis

Yuan, Mengqin; Liu, Haizhou; Zhou, Shunheng; Xu, Zhou; Huang, Yue; Hou, Fei; Jiang, Wei

doi:10.3390/ijms21207585

Cited by 5 publications

(5 citation statements)

References 65 publications

(87 reference statements)

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“…RWV exposure of PBMC results in a multi-cellular immunosuppressive response that may contribute to the impairment of the immune system and the defense against pathogens [ 144 ]. A further study investigated transcriptional and post-transcriptional regulations based on gene and miRNA expression profiles in human peripheral blood lymphocytes exposed to the RWV [ 145 ]. Two hundred and thirty dysregulated TF-miRNA (transcription factor and microRNA) feed-forward loops (FFLs) were identified in s-µ g .…”

Section: Resultsmentioning

confidence: 99%

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Current Knowledge about the Impact of Microgravity on Gene Regulation

Corydon

Schulz

Richter

et al. 2023

Cells

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Microgravity (µg) has a massive impact on the health of space explorers. Microgravity changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into deep space are being planned along with the commercialization of space travelling, researchers have focused on gene regulation in cells and organisms exposed to real (r-) and simulated (s-) µg. In particular, cancer and metastasis research benefits from the findings obtained under µg conditions. Gene regulation is a key factor in a cell or an organism’s ability to sustain life and respond to environmental changes. It is a universal process to control the amount, location, and timing in which genes are expressed. In this review, we provide an overview of µg-induced changes in the numerous mechanisms involved in gene regulation, including regulatory proteins, microRNAs, and the chemical modification of DNA. In particular, we discuss the current knowledge about the impact of microgravity on gene regulation in different types of bacteria, protists, fungi, animals, humans, and cells with a focus on the brain, eye, endothelium, immune system, cartilage, muscle, bone, and various cancers as well as recent findings in plants. Importantly, the obtained data clearly imply that µg experiments can support translational medicine on Earth.

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Section: Resultsmentioning

confidence: 99%

“…Two hundred and thirty dysregulated TF-miRNA (transcription factor and microRNA) feed-forward loops (FFLs) were identified in s-µ g . Associations of RWV exposure with dysfunctions of multi-body systems and tumorigenesis were reported [ 145 ].…”

Section: Resultsmentioning

confidence: 99%

Current Knowledge about the Impact of Microgravity on Gene Regulation

Corydon

Schulz

Richter

et al. 2023

Cells

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“…Combining these novel technologies with microgravity platforms could be used to uncover immunotherapy drug targets and provide further insight into disease specific immune responses. Research has shown that microgravity has a positive impact on combating diseases such as cancer by regulating cancer cell proliferating and survival [142][143][144]. The mechanisms found can be used to benefit cancer treatment on Earth.…”

Section: Technological Advances For Future Microgravity Researchmentioning

confidence: 99%

May the Force Be with You (Or Not): The Immune System under Microgravity

ElGindi

Sapudom

Ibrahim

et al. 2021

Cells

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All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force. Due to the increase of crewed space flights in recent years, it is vital to understand how the lack of gravitational forces affects organisms. It is known that astronauts who have been exposed to microgravity suffer from an array of pathological conditions including an impaired immune system, which is one of the most negatively affected by microgravity. However, at the cellular level a gap in knowledge exists, limiting our ability to understand immune impairment in space. This review highlights the most significant work done over the past 10 years detailing the effects of microgravity on cellular aspects of the immune system.

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“…Another study used systems biological methods and performed an integrative analysis of regulatory module and found associations of µg with dysfunctions of various systems and tumorigenesis [19]. Analysis of the skeletal system revealed that most of the genes and miRNAs in the subnetwork were involved in bone loss.…”

Section: Breast Cancer Cells In Microgravity: New Aspects For Cancer Researchmentioning

confidence: 99%

“…Analysis of the skeletal system revealed that most of the genes and miRNAs in the subnetwork were involved in bone loss. The analysis of the relationship between µg (RWV) and 20 cancer types showed that most cancers might be promoted by µg [19].…”

Section: Breast Cancer Cells In Microgravity: New Aspects For Cancer Researchmentioning

confidence: 99%